HitPredict

Interactor 1: PDIA6 (Q15084)
Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7)
Gene: PDIA6

Interactor 2: TRXR1 (Q16881)
Thioredoxin reductase 1, cytoplasmic (TR) (EC 1.8.1.9) (Gene associated with retinoic and interferon-induced mortality 12 protein) (GRIM-12) (Gene associated with retinoic and IFN-induced mortality 12 protein) (KM-102-derived reductase-like factor) (Peroxidase TXNRD1) (EC 1.11.1.2) (Thioredoxin reductase TR1)
Gene: TXNRD1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pyr_redox_2~Thioredoxin, Pyr_redox_dim~Thioredoxin
Common GO terms	GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 440 Hs			1 649
+	Hs
		452782 PDIA6_HUMAN (1-440): 1.21e-134: 396: 100.00		DLDH_HUMAN (145-642): 8.45e-138: 414: 28.12
+	Dm
		870421 PDI_DROME (62-390): 1.17e-12: 71.5: 11.78		TRXR1_DROME (146-647): 8.46e-164: 483: 53.68