HitPredict

Interactor 1: PDIA6 (Q15084)
Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7)
Gene: PDIA6

Interactor 2: CALR3 (Q96L12)
Calreticulin-3 (Calreticulin-2) (Calsperin)
Gene: CALR3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	31056421, 34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005788 - endoplasmic reticulum lumen GO:0005789 - endoplasmic reticulum membrane GO:0006457 - protein folding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 440 Hs			1 384
+	Hs
		653597 PDIA6_HUMAN (1-440): 1.21e-134: 396: 100.00		CALR_HUMAN (18-348): 5e-156: 447: 51.88
+	Dm
		667040 PDIA6_DROME (1-423): 1.46e-112: 339: 56.91		CALR_DROME (8-365): 2.58e-144: 417: 41.56
+	Dm
		1359553 PDIA6_DROME (1-423): 1.46e-112: 339: 56.91		Q9VAL7_DROME (22-355): 4.6e-120: 362: 26.51
+	Hs
		1240407 TXND5_HUMAN (177-431): 3.21e-41: 153: 20.37		CALR3_HUMAN (1-384): 0: 543: 100.00
+	Hs
		1220455 DJC10_HUMAN (119-381): 3.95e-19: 92.3: 20.68		CALR3_HUMAN (1-384): 0: 543: 100.00
+	Hs
		531950 PDIA4_HUMAN (67-271): 1.28e-17: 87.3: 22.28		CALR3_HUMAN (1-384): 0: 543: 100.00
+	Hs
		1055308 PDIA5_HUMAN (153-431): 3.2e-11: 67.2: 13.01		CALR3_HUMAN (1-384): 0: 543: 100.00
+	Hs
		423330 PDIA1_HUMAN (62-387): 6.18e-10: 63: 11.59		CALR3_HUMAN (1-384): 0: 543: 100.00
+	Hs
		653650 DJC10_HUMAN (119-381): 3.95e-19: 92.3: 20.68		CALR_HUMAN (18-348): 5e-156: 447: 51.88
+	Hs
		531728 PDIA4_HUMAN (67-271): 1.28e-17: 87.3: 22.28		CALR_HUMAN (18-348): 5e-156: 447: 51.88
+	Hs
		653695 TMX3_HUMAN (3-127): 8.56e-18: 87: 35.94		CALR_HUMAN (18-348): 5e-156: 447: 51.88
+	Dm
		667020 Q3YMU0_DROME (21-145): 4.46e-23: 103: 29.92		CALR_DROME (8-365): 2.58e-144: 417: 41.56
+	Hs
		653491 PDIA3_HUMAN (13-386): 9.31e-10: 62.6: 11.02		CALR_HUMAN (18-348): 5e-156: 447: 51.88
+	Dm
		667013 PDI_DROME (62-390): 1.17e-12: 71.5: 11.78		CALR_DROME (8-365): 2.58e-144: 417: 41.56
+	At
		137900 PDI21_ARATH (281-437): 3.77e-12: 69.2: 11.47		CALR1_ARATH (3-341): 3.11e-144: 417: 38.94
+	Hs
		654519 DJC10_HUMAN (119-381): 3.95e-19: 92.3: 20.68		CALX_HUMAN (16-357): 7.28e-123: 368: 26.73
+	Hs
		531729 PDIA4_HUMAN (67-271): 1.28e-17: 87.3: 22.28		CALX_HUMAN (16-357): 7.28e-123: 368: 26.73
+	Hs
		654668 TMX3_HUMAN (3-127): 8.56e-18: 87: 35.94		CALX_HUMAN (16-357): 7.28e-123: 368: 26.73
+	Rn
		514119 PDIA3_RAT (13-386): 4.34e-11: 66.8: 10.71		CALX_RAT (16-357): 1.96e-122: 367: 26.97
+	Hs
		423150 PDIA1_HUMAN (62-387): 6.18e-10: 63: 11.59		CALX_HUMAN (16-357): 7.28e-123: 368: 26.73