HitPredict

Interactor 1: PDK1 (Q15118)
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1)
Gene: PDK1

Interactor 2: PDK1 (Q15118)
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1)
Gene: PDK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.70 1.00 0.840

The method score is based on:

Property Details
Experiments 29568061, 18003900, 17683942
Identification Methods proximity labelling technology, enzymatic study, x-ray crystallography
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains BCDHK_Adom3~HATPase_c, HATPase_c~HATPase_c
Common GO terms GO:0004672 - protein kinase activity
GO:0004740 - pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
and 7 others

more...
Homologous interactions 11

Homologous interactions

Color coding for hit scores

1 436
Hs

1 436
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Sc

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024