HitPredict

Interactor 1: PDK1 (Q15118)
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1)
Gene: PDK1

Interactor 2: PKN2 (Q16513)
Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2)
Gene: PKN2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	10753910, 17110931
Identification Methods	affinity chromatography technology, protein kinase assay
Interaction Type	physical association, phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0004672 - protein kinase activity GO:0005524 - ATP binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 436 Hs			1 984
+	Hs
		1067965 PDK1_HUMAN (1-436): 0: 674: 100.00		PKN1_HUMAN (15-984): 0: 940: 56.24
+	Hs
		117006 PDK1_HUMAN (1-436): 0: 674: 100.00		SGK1_HUMAN (611-979): 8.56e-147: 444: 38.67
+	Rn
		932095 PDK1_RAT (1-436): 0: 684: 92.20		KS6B1_RAT (397-670): 1.09e-27: 120: 12.04
+	Hs
		616710 PDK1_HUMAN (1-436): 0: 674: 100.00		KS6B1_HUMAN (397-670): 1.04e-27: 120: 12.04
+	Hs
		682176 PDK1_HUMAN (1-436): 0: 674: 100.00		AKT2_HUMAN (364-610): 4.79e-17: 87.5: 10.84
+	Hs
		681855 PDK1_HUMAN (1-436): 0: 674: 100.00		AKT1_HUMAN (397-605): 8.1e-17: 86.7: 10.70
+	Hs
		408617 PDK1_HUMAN (1-436): 0: 674: 100.00		KPCB_HUMAN (397-486): 3.14e-12: 72.4: 14.44