HitPredict

Interactor 1: CDK10 (Q15131)
Cyclin-dependent kinase 10 (EC 2.7.11.22) (Cell division protein kinase 10) (Serine/threonine-protein kinase PISSLRE)
Gene: CDK10

Interactor 2: CDC37 (Q16543)
Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) [Cleaved into: Hsp90 co-chaperone Cdc37, N-terminally processed]
Gene: CDC37

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	33961781, 25036637
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, luminescence based mammalian interactome mapping
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CDC37_M~Pkinase, CDC37_N~Pkinase
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 360 Hs			1 378
+	Hs
		625464 CDK2_HUMAN (36-331): 1.52e-139: 399: 43.43		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		596761 CD11B_HUMAN (30-353): 3.8e-132: 398: 53.64		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		1083048 CD11A_HUMAN (30-353): 4.46e-132: 397: 53.33		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		414935 CDK1_HUMAN (36-332): 2.51e-130: 376: 39.47		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		960287 CDK5_HUMAN (36-329): 9.05e-129: 372: 43.39		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00
+	Hs
		841214 CDK7_HUMAN (37-329): 5.56e-77: 242: 42.91		CDC37_HUMAN (1-378): 2.03e-169: 479: 100.00