HitPredict

Interactor 1: KPCD1 (Q15139)
Serine/threonine-protein kinase D1 (EC 2.7.11.13) (Protein kinase C mu type) (Protein kinase D) (nPKC-D1) (nPKC-mu)
Gene: PRKD1

Interactor 2: NHRF2 (Q15599)
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1)
Gene: NHERF2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	27173435, 33961781
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005886 - plasma membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 912 Hs			1 337
+	Hs
		1075453 KPCD2_HUMAN (7-912): 0: 795: 66.52		NHRF2_HUMAN (1-337): 6.02e-79: 246: 100.00
+	Hs
		1296894 KPCD2_HUMAN (7-912): 0: 795: 66.52		SNX27_HUMAN (149-228): 1.89e-09: 60.8: 38.71
+	Hs
		153882 AKT1_HUMAN (423-904): 2.81e-136: 417: 23.81		NHRF1_HUMAN (2-337): 3.61e-70: 224: 48.87
+	Hs
		681891 AKT1_HUMAN (423-904): 2.81e-136: 417: 23.81		NHRF3_HUMAN (148-263): 7.43e-11: 65: 28.45
+	Hs
		682200 AKT2_HUMAN (422-904): 2.15e-136: 418: 23.91		SNX27_HUMAN (149-228): 1.89e-09: 60.8: 38.71
+	Dm
		677687 KCC2A_DROME (577-839): 5.04e-115: 364: 36.33		DLG1_DROME (12-325): 4.79e-25: 108: 16.57
+	Mm
		1143346 KCC2D_MOUSE (577-909): 4.84e-116: 365: 30.64		DLG4_MOUSE (106-233): 1.85e-14: 76.2: 21.48
+	Hs
		566396 KPCA_HUMAN (54-212): 8.55e-22: 103: 19.50		NHRF2_HUMAN (1-337): 6.02e-79: 246: 100.00
+	Hs
		153871 KPCA_HUMAN (54-212): 8.55e-22: 103: 19.50		NHRF1_HUMAN (2-337): 3.61e-70: 224: 48.87
+	Dm
		397196 KPC1_DROME (53-204): 1.39e-21: 102: 19.87		Q9VX75_DROME (28-333): 2.4e-36: 141: 22.47
+	Mm
		554913 KPCE_MOUSE (20-282): 9.88e-32: 134: 17.54		DLG4_MOUSE (106-233): 1.85e-14: 76.2: 21.48
+	Mm
		934625 KPCB_MOUSE (17-468): 3.14e-25: 114: 12.45		DLG4_MOUSE (106-233): 1.85e-14: 76.2: 21.48
+	Mm
		934628 KPCB_MOUSE (17-468): 3.14e-25: 114: 12.45		INADL_MOUSE (8-129): 5.85e-13: 71.9: 21.88
+	Mm
		930567 KPCG_MOUSE (54-232): 1.58e-22: 105: 20.77		DLG4_MOUSE (106-233): 1.85e-14: 76.2: 21.48
+	Rn
		404387 KPCA_RAT (54-212): 8.48e-22: 103: 19.50		DLG4_RAT (106-233): 1.75e-14: 76.2: 21.48
+	Hs
		566353 KPCA_HUMAN (54-212): 8.55e-22: 103: 19.50		DLG4_HUMAN (106-233): 1.85e-14: 76.2: 21.48
+	Hs
		566388 KPCA_HUMAN (54-212): 8.55e-22: 103: 19.50		SCRIB_HUMAN (4-185): 3.63e-13: 72.7: 18.37
+	Rn
		404390 KPCA_RAT (54-212): 8.48e-22: 103: 19.50		DLG3_RAT (103-220): 4.99e-09: 59.6: 20.00