HitPredict

Interactor 1: PLCB4 (Q15147)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-4) (Phospholipase C-beta-4) (PLC-beta-4)
Gene: PLCB4

Interactor 2: RHOH (Q15669)
Rho-related GTP-binding protein RhoH (GTP-binding protein TTF) (Translocation three four protein)
Gene: RHOH

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH_14~Ras
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1175 Hs			1 191
+	Hs
		436313 PLCB4_HUMAN (1-1175): 0: 1180: 100.00		RHOC_HUMAN (6-185): 6.48e-85: 250: 42.25
+	Hs
		915688 PLCB4_HUMAN (1-1175): 0: 1180: 100.00		RHOB_HUMAN (6-191): 6.57e-85: 250: 40.93
+	Hs
		925291 PLCB4_HUMAN (1-1175): 0: 1180: 100.00		RAC1_HUMAN (2-191): 2.63e-75: 226: 39.09
+	Hs
		564537 PLCB4_HUMAN (1-1175): 0: 1180: 100.00		RHOQ_HUMAN (5-190): 8.15e-74: 222: 39.49
+	Hs
		894028 PLCB4_HUMAN (1-1175): 0: 1180: 100.00		CDC42_HUMAN (2-181): 1.52e-73: 221: 42.25
+	Hs
		545390 PLCB4_HUMAN (1-1175): 0: 1180: 100.00		RAC2_HUMAN (2-191): 1.96e-72: 218: 38.07
+	Hs
		892383 PLCB4_HUMAN (1-1175): 0: 1180: 100.00		RAC3_HUMAN (2-171): 3.86e-72: 218: 41.81
+	Hs
		951009 PLCB4_HUMAN (1-1175): 0: 1180: 100.00		RHOG_HUMAN (2-191): 2.32e-71: 216: 37.56
+	Hs
		900491 PLCB4_HUMAN (1-1175): 0: 1180: 100.00		RHOA_HUMAN (6-191): 8.9e-71: 214: 39.38
+	Hs
		925200 PLCB2_HUMAN (9-1169): 0: 999: 33.90		RAC1_HUMAN (2-191): 2.63e-75: 226: 39.09
+	Hs
		915998 PLCB1_HUMAN (2-1175): 0: 937: 37.46		RHOB_HUMAN (6-191): 6.57e-85: 250: 40.93
+	Hs
		915719 PLCH1_HUMAN (15-924): 0: 788: 26.19		RHOB_HUMAN (6-191): 6.57e-85: 250: 40.93
+	Hs
		900537 PLCH1_HUMAN (15-924): 0: 788: 26.19		RHOA_HUMAN (6-191): 8.9e-71: 214: 39.38
+	Hs
		580973 PLCG1_HUMAN (559-817): 5.45e-80: 289: 35.58		RAC1_HUMAN (2-191): 2.63e-75: 226: 39.09
+	Hs
		580968 PLCG1_HUMAN (559-817): 5.45e-80: 289: 35.58		RHOA_HUMAN (6-191): 8.9e-71: 214: 39.38
+	Hs
		925208 PLCB3_HUMAN (835-1076): 2.9e-12: 73.6: 12.35		RAC1_HUMAN (2-191): 2.63e-75: 226: 39.09
+	Hs
		545329 PLCB3_HUMAN (835-1076): 2.9e-12: 73.6: 12.35		RAC2_HUMAN (2-191): 1.96e-72: 218: 38.07