HitPredict

Interactor 1: PLCB4 (Q15147)
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-4) (Phospholipase C-beta-4) (PLC-beta-4)
Gene: PLCB4

Interactor 2: RHOV (Q96L33)
Rho-related GTP-binding protein RhoV (CDC42-like GTPase 2) (GTP-binding protein-like 2) (Rho GTPase-like protein ARHV) (Wnt-1 responsive Cdc42 homolog 2) (WRCH-2)
Gene: RHOV

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH_14~Ras
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 1175 Hs			1 236
+	Hs
		951009 PLCB4_HUMAN (1-1175): 0: 1180: 100.00		RHOG_HUMAN (31-210): 1.12e-78: 236: 49.44
+	Hs
		925291 PLCB4_HUMAN (1-1175): 0: 1180: 100.00		RAC1_HUMAN (32-217): 3.34e-76: 230: 53.23
+	Hs
		892383 PLCB4_HUMAN (1-1175): 0: 1180: 100.00		RAC3_HUMAN (32-206): 6.17e-74: 224: 56.00
+	Hs
		564537 PLCB4_HUMAN (1-1175): 0: 1180: 100.00		RHOQ_HUMAN (23-236): 1.99e-73: 223: 50.00
+	Hs
		545390 PLCB4_HUMAN (1-1175): 0: 1180: 100.00		RAC2_HUMAN (32-216): 6.11e-73: 222: 52.43
+	Hs
		900491 PLCB4_HUMAN (1-1175): 0: 1180: 100.00		RHOA_HUMAN (33-215): 9.31e-73: 221: 42.62
+	Hs
		894028 PLCB4_HUMAN (1-1175): 0: 1180: 100.00		CDC42_HUMAN (32-207): 2.12e-66: 205: 57.39
+	Hs
		1068532 PLCB4_HUMAN (1-1175): 0: 1180: 100.00		RHOJ_HUMAN (32-214): 8.3e-59: 186: 50.27
+	Hs
		925200 PLCB2_HUMAN (9-1169): 0: 999: 33.90		RAC1_HUMAN (32-217): 3.34e-76: 230: 53.23
+	Hs
		900537 PLCH1_HUMAN (15-924): 0: 788: 26.19		RHOA_HUMAN (33-215): 9.31e-73: 221: 42.62
+	Hs
		581019 PLCG1_HUMAN (559-817): 5.45e-80: 289: 35.58		RHOU_HUMAN (32-236): 2.81e-89: 265: 60.48
+	Hs
		580973 PLCG1_HUMAN (559-817): 5.45e-80: 289: 35.58		RAC1_HUMAN (32-217): 3.34e-76: 230: 53.23
+	Hs
		580968 PLCG1_HUMAN (559-817): 5.45e-80: 289: 35.58		RHOA_HUMAN (33-215): 9.31e-73: 221: 42.62
+	Hs
		925208 PLCB3_HUMAN (835-1076): 2.9e-12: 73.6: 12.35		RAC1_HUMAN (32-217): 3.34e-76: 230: 53.23
+	Hs
		545329 PLCB3_HUMAN (835-1076): 2.9e-12: 73.6: 12.35		RAC2_HUMAN (32-216): 6.11e-73: 222: 52.43