HitPredict

Interactor 1: PLEC (Q15149)
Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1)
Gene: PLEC

Interactor 2: ESR2 (Q92731)
Estrogen receptor beta (ER-beta) (Nuclear receptor subfamily 3 group A member 2)
Gene: ESR2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.50	0.549

Property	Details
Experiments	21951318, 25604459
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 4684 Hs			1 530
+	Hs
		369641 PLEC_HUMAN (1-4684): 0: 1783: 100.00		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		993279 ACTN3_HUMAN (166-893): 2.36e-146: 484: 25.79		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		521591 ACTN1_HUMAN (153-876): 1.96e-112: 384: 23.94		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		368893 ACTN1_HUMAN (153-876): 1.96e-112: 384: 23.94		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		521532 ACTN1_HUMAN (153-876): 1.96e-112: 384: 23.94		NR1H3_HUMAN (65-499): 1.77e-104: 322: 20.97
+	Hs
		885285 EPIPL_HUMAN (3039-3941): 6.03e-42: 174: 27.75		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		369273 EPIPL_HUMAN (3039-3941): 6.03e-42: 174: 27.75		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		164649 SPTN2_HUMAN (1390-3166): 2.85e-25: 118: 12.24		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		1059246 GOGB1_HUMAN (2666-3718): 4.33e-13: 78.9: 11.65		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		974119 DYST_HUMAN (4185-4600): 1.51e-10: 70.4: 18.51		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		1269937 MACF1_HUMAN (3704-4616): 3.72e-10: 69.3: 14.92		ESR2_HUMAN (1-530): 2.38e-157: 460: 100.00
+	Hs
		369420 SPTB2_HUMAN (1531-3349): 2.4e-17: 92.7: 9.53		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		369619 GOGB1_HUMAN (2666-3718): 4.33e-13: 78.9: 11.65		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		369446 DYST_HUMAN (4185-4600): 1.51e-10: 70.4: 18.51		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		370715 MACF1_HUMAN (3704-4616): 3.72e-10: 69.3: 14.92		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		368926 DESP_HUMAN (351-874): 8.53e-10: 68.1: 8.21		ESR1_HUMAN (9-529): 3.58e-138: 413: 44.56
+	Hs
		510045 MACF1_HUMAN (3704-4616): 3.72e-10: 69.3: 14.92		ERR1_HUMAN (85-497): 1.88e-112: 342: 35.65
+	Hs
		320227 SPTN4_HUMAN (1394-3173): 6.68e-13: 78.1: 10.95		ERR2_HUMAN (69-499): 5.86e-109: 333: 31.57
+	Hs
		377068 DESP_HUMAN (351-874): 8.53e-10: 68.1: 8.21		GCR_HUMAN (3-495): 1.12e-103: 330: 22.64
+	Hs
		487276 EPIPL_HUMAN (3039-3941): 6.03e-42: 174: 27.75		ANDR_HUMAN (149-407): 8.1e-38: 150: 32.59