HitPredict

Interactor 1: NH114 (G5EEM0)
Nuclear hormone receptor 114
Gene: nhr-114

Interactor 2: NHR49 (O45666)
Nuclear hormone receptor family member nhr-49
Gene: nhr-49

Species: Caenorhabditis elegans

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	23791784
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Hormone_recep~Hormone_recep, Hormone_recep~zf-C4, zf-C4~zf-C4
Common GO terms	GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0004879 - nuclear receptor activity GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II GO:0008270 - zinc ion binding and 1 others more... GO:0030154 - cell differentiation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 418 Ce			1 501
+	Ce
		106935 NH114_CAEEL (1-418): 2.64e-131: 385: 100.00		H2KZA1_CAEEL (14-483): 6.33e-103: 322: 28.78
+	Ce
		106960 NH114_CAEEL (1-418): 2.64e-131: 385: 100.00		NHR31_CAEEL (4-485): 3.26e-94: 299: 23.87
+	Ce
		106915 NH114_CAEEL (1-418): 2.64e-131: 385: 100.00		G5EEL3_CAEEL (34-419): 1.66e-95: 296: 24.26
+	Ce
		106933 NH114_CAEEL (1-418): 2.64e-131: 385: 100.00		NH114_CAEEL (21-426): 1.22e-93: 292: 24.16
+	Hs
		587112 RXRA_HUMAN (3-409): 2.8e-100: 308: 22.30		RXRA_HUMAN (1-423): 1.18e-104: 322: 27.66
+	Hs
		587136 RXRA_HUMAN (3-409): 2.8e-100: 308: 22.30		RXRG_HUMAN (1-420): 1.61e-101: 314: 28.20
+	Ce
		785440 NHR10_CAEEL (2-411): 1.62e-108: 326: 55.23		NHR10_CAEEL (19-421): 1.59e-95: 296: 28.01
+	Hs
		368969 RXRA_HUMAN (3-409): 2.8e-100: 308: 22.30		ESR1_HUMAN (14-467): 1.59e-96: 305: 19.87
+	Hs
		368869 COT1_HUMAN (2-413): 4.92e-100: 306: 18.93		ESR1_HUMAN (14-467): 1.59e-96: 305: 19.87
+	Bt
		836372 COT1_BOVIN (2-413): 1.22e-99: 305: 18.93		ESR1_BOVIN (19-467): 4.71e-95: 301: 20.87
+	Ce
		137568 NHR4_CAEEL (2-416): 1.82e-99: 307: 21.23		NHR62_CAEEL (35-420): 4.05e-92: 291: 23.19
+	Hs
		500354 RXRA_HUMAN (3-409): 2.8e-100: 308: 22.30		RARB_HUMAN (7-450): 1.31e-91: 288: 21.32
+	Mm
		659690 RXRA_MOUSE (3-409): 1.65e-101: 311: 22.30		NR1H3_MOUSE (12-418): 1.1e-90: 285: 21.95
+	Mm
		659674 RXRA_MOUSE (3-409): 1.65e-101: 311: 22.30		THB_MOUSE (7-421): 5.33e-89: 282: 19.38
+	Hs
		490049 RXRA_HUMAN (3-409): 2.8e-100: 308: 22.30		NR2F6_HUMAN (11-430): 3.42e-90: 283: 23.90
+	Ce
		220027 NHR4_CAEEL (2-416): 1.82e-99: 307: 21.23		NHR61_CAEEL (35-418): 3.7e-90: 283: 21.63
+	Hs
		500461 RXRA_HUMAN (3-409): 2.8e-100: 308: 22.30		THB_HUMAN (7-421): 7.83e-89: 281: 19.62
+	Hs
		587144 RXRA_HUMAN (3-409): 2.8e-100: 308: 22.30		NR1H2_HUMAN (14-418): 7.12e-89: 281: 21.66
+	Hs
		587209 RXRA_HUMAN (3-409): 2.8e-100: 308: 22.30		NR2E3_HUMAN (30-421): 3.19e-89: 281: 25.45
+	Hs
		587162 RXRA_HUMAN (3-409): 2.8e-100: 308: 22.30		NR1H3_HUMAN (9-418): 1.31e-88: 280: 21.22