HitPredict

Interactor 1: NONO (Q15233)
Non-POU domain-containing octamer-binding protein (NonO protein) (54 kDa nuclear RNA- and DNA-binding protein) (p54(nrb)) (p54nrb) (55 kDa nuclear protein) (NMT55) (DNA-binding p52/p100 complex, 52 kDa subunit)
Gene: NONO

Interactor 2: HDAC6 (Q9UBN7)
Histone deacetylase 6 (HD6) (EC 3.5.1.98) (Protein deacetylase HDAC6) (EC 3.5.1.-) (Tubulin-lysine deacetylase HDAC6) (EC 3.5.1.-)
Gene: HDAC6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	26643866, 35676659
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 471 Hs			1 1215
+	Hs
		1031484 PABP4_HUMAN (66-467): 1.55e-70: 237: 15.42		HDAC6_HUMAN (1-1215): 0: 1435: 100.00
+	Hs
		1263571 PSPC1_HUMAN (20-470): 2.17e-67: 226: 58.41		HDAC6_HUMAN (1-1215): 0: 1435: 100.00
+	Hs
		516723 PABP1_HUMAN (66-459): 7.11e-65: 222: 14.89		HDAC6_HUMAN (1-1215): 0: 1435: 100.00
+	Hs
		613605 SFPQ_HUMAN (45-471): 3.15e-53: 192: 56.92		HDAC6_HUMAN (1-1215): 0: 1435: 100.00
+	Hs
		1077527 ELAV1_HUMAN (68-205): 7.38e-47: 166: 27.82		HDAC6_HUMAN (1-1215): 0: 1435: 100.00
+	Hs
		1038399 NONO_HUMAN (1-471): 1.15e-97: 303: 100.00		HDAC1_HUMAN (478-896): 4.05e-166: 503: 20.09
+	Hs
		1069756 NONO_HUMAN (1-471): 1.15e-97: 303: 100.00		HDAC2_HUMAN (78-489): 1.04e-157: 481: 21.02
+	Hs
		1069827 NONO_HUMAN (1-471): 1.15e-97: 303: 100.00		HDAC5_HUMAN (33-471): 3.29e-145: 469: 32.48
+	Hs
		177300 NONO_HUMAN (1-471): 1.15e-97: 303: 100.00		HDAC3_HUMAN (479-890): 6.6e-146: 448: 18.29
+	Hs
		1031410 PABP4_HUMAN (66-467): 1.55e-70: 237: 15.42		HDAC2_HUMAN (78-489): 1.04e-157: 481: 21.02
+	Hs
		516618 PABP1_HUMAN (66-459): 7.11e-65: 222: 14.89		HDAC2_HUMAN (78-489): 1.04e-157: 481: 21.02
+	Hs
		613443 SFPQ_HUMAN (45-471): 3.15e-53: 192: 56.92		HDAC1_HUMAN (478-896): 4.05e-166: 503: 20.09
+	Hs
		516750 PABP1_HUMAN (66-459): 7.11e-65: 222: 14.89		HDAC5_HUMAN (33-471): 3.29e-145: 469: 32.48
+	Mm
		1143073 ELAV4_MOUSE (40-205): 7.55e-60: 202: 28.02		HDAC4_MOUSE (424-873): 9e-152: 485: 37.16
+	Hs
		613536 SFPQ_HUMAN (45-471): 3.15e-53: 192: 56.92		HDAC2_HUMAN (78-489): 1.04e-157: 481: 21.02
+	Hs
		613620 SFPQ_HUMAN (45-471): 3.15e-53: 192: 56.92		HDAC5_HUMAN (33-471): 3.29e-145: 469: 32.48
+	Mm
		1141838 ELAV3_MOUSE (54-270): 1.01e-47: 170: 22.03		HDAC4_MOUSE (424-873): 9e-152: 485: 37.16
+	Mm
		936682 ELAV1_MOUSE (68-205): 2.05e-46: 165: 28.48		HDAC4_MOUSE (424-873): 9e-152: 485: 37.16
+	Hs
		880739 ELAV1_HUMAN (68-205): 7.38e-47: 166: 27.82		HDAC4_HUMAN (405-873): 1.97e-147: 474: 36.51
+	Sc
		376692 PABP_YEAST (30-384): 3.77e-37: 145: 16.50		RPD3_YEAST (75-473): 1.1e-149: 458: 20.24