HitPredict

Interactor 1: PWP2 (Q15269)
Periodic tryptophan protein 2 homolog
Gene: PWP2

Interactor 2: WDR75 (Q8IWA0)
WD repeat-containing protein 75 (U3 small nucleolar RNA-associated protein 17 homolog)
Gene: WDR75

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	WD40~WD40
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0032040 - small-subunit processome GO:0042274 - ribosomal small subunit biogenesis
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 919 Hs			1 830
+	Sc
		635629 PWP2_YEAST (1-889): 0: 565: 41.96		UTP17_YEAST (18-530): 4.03e-84: 289: 19.26
+	Hs
		1016282 PWP2_HUMAN (1-919): 0: 595: 100.00		TBL3_HUMAN (1-491): 1e-71: 253: 11.49
+	Hs
		1070055 PWP2_HUMAN (1-919): 0: 595: 100.00		WDR3_HUMAN (510-738): 3.01e-19: 95.4: 15.95
+	Dm
		1137156 Q5U0X8_DROME (1-915): 3.4e-173: 529: 45.15		Q7JQT9_DROME (108-671): 1.38e-39: 159: 11.28
+	Sc
		635548 PWP2_YEAST (1-889): 0: 565: 41.96		PWP2_YEAST (24-470): 4.2e-25: 113: 13.62
+	Sc
		635670 PWP2_YEAST (1-889): 0: 565: 41.96		UTP12_YEAST (393-613): 1.05e-23: 109: 13.33
+	Hs
		1240442 POC1B_HUMAN (2-255): 6.74e-59: 211: 15.56		POC1A_HUMAN (1-181): 2.15e-35: 141: 17.39
+	Hs
		245633 TBL1X_HUMAN (411-723): 7.49e-36: 145: 16.56		TBL1R_HUMAN (329-669): 7.31e-53: 194: 10.14
+	Hs
		245630 TBL1X_HUMAN (411-723): 7.49e-36: 145: 16.56		TBL1Y_HUMAN (324-669): 3.68e-52: 192: 11.11
+	Hs
		1309163 TBL1R_HUMAN (409-723): 2.71e-34: 140: 18.56		TBL1Y_HUMAN (324-669): 3.68e-52: 192: 11.11
+	Hs
		725410 COPB2_HUMAN (491-777): 1.86e-42: 169: 7.22		WDR5_HUMAN (477-696): 2.27e-34: 136: 15.25
+	Dm
		1358845 WDS_DROME (592-854): 5.77e-33: 133: 10.15		WDS_DROME (437-660): 3.66e-42: 159: 13.60
+	Hs
		792949 LIS1_HUMAN (96-403): 5.85e-37: 146: 14.89		WDR5_HUMAN (477-696): 2.27e-34: 136: 15.25
+	Mm
		925836 LIS1_MOUSE (96-403): 5.03e-37: 146: 14.89		LIS1_MOUSE (475-709): 2.28e-32: 132: 10.92
+	Hs
		792935 LIS1_HUMAN (96-403): 5.85e-37: 146: 14.89		LIS1_HUMAN (475-709): 2.67e-32: 131: 10.92
+	Hs
		245546 TBL1X_HUMAN (411-723): 7.49e-36: 145: 16.56		TBL1X_HUMAN (396-696): 3.68e-30: 128: 13.74
+	Hs
		725400 COPB2_HUMAN (491-777): 1.86e-42: 169: 7.22		COPA_HUMAN (5-364): 2.65e-16: 86: 12.59
+	Sp
		999842 TUP11_SCHPO (45-361): 1.05e-27: 121: 16.62		TUP12_SCHPO (473-676): 4.26e-20: 97.2: 12.74
+	Sp
		999838 TUP11_SCHPO (45-361): 1.05e-27: 121: 16.62		TUP11_SCHPO (497-707): 2.34e-18: 91.8: 12.73