HitPredict

Interactor 1: PWP2 (Q15269)
Periodic tryptophan protein 2 homolog
Gene: PWP2

Interactor 2: WDR3 (Q9UNX4)
WD repeat-containing protein 3
Gene: WDR3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Utp12~Utp12, ANAPC4_WD40~WD40
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0032040 - small-subunit processome GO:0034388 - Pwp2p-containing subcomplex of 90S preribosome GO:0042274 - ribosomal small subunit biogenesis
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 919 Hs			1 943
+	Dm
		1137157 Q5U0X8_DROME (1-915): 3.4e-173: 529: 45.15		Q9VE98_DROME (1-924): 9.63e-153: 476: 39.96
+	Sc
		635548 PWP2_YEAST (1-889): 0: 565: 41.96		PWP2_YEAST (6-470): 7.57e-65: 237: 13.40
+	Sc
		635670 PWP2_YEAST (1-889): 0: 565: 41.96		UTP12_YEAST (6-266): 4.57e-50: 193: 13.93
+	Sc
		635644 PWP2_YEAST (1-889): 0: 565: 41.96		UTP13_YEAST (2-445): 4.99e-45: 177: 11.38
+	Dm
		1137156 Q5U0X8_DROME (1-915): 3.4e-173: 529: 45.15		Q7JQT9_DROME (4-481): 7.68e-54: 203: 11.18
+	Hs
		1016282 PWP2_HUMAN (1-919): 0: 595: 100.00		TBL3_HUMAN (4-93): 1.78e-17: 89.6: 13.33
+	Hs
		1240442 POC1B_HUMAN (2-255): 6.74e-59: 211: 15.56		POC1A_HUMAN (220-557): 9.69e-58: 205: 13.12
+	Hs
		792935 LIS1_HUMAN (96-403): 5.85e-37: 146: 14.89		LIS1_HUMAN (187-484): 3.35e-46: 173: 11.78
+	Mm
		925836 LIS1_MOUSE (96-403): 5.03e-37: 146: 14.89		LIS1_MOUSE (187-484): 2.71e-46: 173: 11.78
+	Hs
		725410 COPB2_HUMAN (491-777): 1.86e-42: 169: 7.22		WDR5_HUMAN (663-860): 4.99e-35: 138: 10.89
+	Hs
		792949 LIS1_HUMAN (96-403): 5.85e-37: 146: 14.89		WDR5_HUMAN (663-860): 4.99e-35: 138: 10.89
+	Dm
		1358845 WDS_DROME (592-854): 5.77e-33: 133: 10.15		WDS_DROME (663-860): 2.63e-34: 137: 11.88
+	Hs
		245633 TBL1X_HUMAN (411-723): 7.49e-36: 145: 16.56		TBL1R_HUMAN (3-138): 9.77e-27: 117: 17.93
+	Sp
		999838 TUP11_SCHPO (45-361): 1.05e-27: 121: 16.62		TUP11_SCHPO (616-835): 6.07e-34: 140: 13.85
+	Sp
		999842 TUP11_SCHPO (45-361): 1.05e-27: 121: 16.62		TUP12_SCHPO (624-835): 5.66e-29: 125: 12.22
+	Hs
		903077 WDR5_HUMAN (1-125): 1.99e-23: 104: 9.66		WDR5_HUMAN (663-860): 4.99e-35: 138: 10.89
+	Hs
		793026 LIS1_HUMAN (96-403): 5.85e-37: 146: 14.89		KTNB1_HUMAN (409-625): 4.3e-09: 62.4: 22.27
+	Dm
		1358859 WDS_DROME (592-854): 5.77e-33: 133: 10.15		FBXW7_DROME (540-707): 6e-09: 62.4: 25.29
+	Hs
		903174 WDR5_HUMAN (1-125): 1.99e-23: 104: 9.66		TBL3_HUMAN (4-93): 1.78e-17: 89.6: 13.33