HitPredict

Interactor 1: RNPS1 (Q15287)
RNA-binding protein with serine-rich domain 1 (SR-related protein LDC2)
Gene: RNPS1

Interactor 2: PUF60 (Q9UHX1)
Poly(U)-binding-splicing factor PUF60 (60 kDa poly(U)-binding-splicing factor) (FUSE-binding protein-interacting repressor) (FBP-interacting repressor) (Ro-binding protein 1) (RoBP1) (Siah-binding protein 1) (Siah-BP1)
Gene: PUF60

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.802

Property	Details
Experiments	17353931, 33961781
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0000381 - regulation of alternative mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 305 Hs			1 559
+	Hs
		1054329 RNPS1_HUMAN (1-234): 2e-34: 128: 100.00		RBM39_HUMAN (113-555): 5.61e-70: 235: 19.78
+	Hs
		1054669 PPIE_HUMAN (159-297): 4.41e-33: 125: 17.73		RBM39_HUMAN (113-555): 5.61e-70: 235: 19.78
+	Hs
		1054620 RFOX1_HUMAN (37-267): 2.95e-31: 122: 12.39		RBM39_HUMAN (113-555): 5.61e-70: 235: 19.78
+	Hs
		198887 RFOX2_HUMAN (44-274): 2.32e-31: 122: 13.25		RBM39_HUMAN (113-555): 5.61e-70: 235: 19.78
+	Hs
		1054716 RBM8A_HUMAN (95-239): 7.02e-31: 115: 21.38		RBM39_HUMAN (113-555): 5.61e-70: 235: 19.78
+	Hs
		853892 NCBP2_HUMAN (128-271): 1.08e-30: 114: 18.06		RBM39_HUMAN (113-555): 5.61e-70: 235: 19.78
+	Hs
		1020261 RNPS1_HUMAN (1-234): 2e-34: 128: 100.00		ELAV2_HUMAN (223-553): 1.56e-45: 165: 14.80
+	Hs
		1020353 PPIE_HUMAN (159-297): 4.41e-33: 125: 17.73		ELAV2_HUMAN (223-553): 1.56e-45: 165: 14.80
+	Hs
		198880 RFOX2_HUMAN (44-274): 2.32e-31: 122: 13.25		ELAV2_HUMAN (223-553): 1.56e-45: 165: 14.80
+	Hs
		1119141 PAP1L_HUMAN (65-252): 9.83e-23: 99: 14.21		PABP5_HUMAN (133-308): 3.43e-45: 165: 23.86
+	Hs
		1070529 RNPS1_HUMAN (1-234): 2e-34: 128: 100.00		Q7Z3L0_HUMAN (62-228): 4.04e-32: 129: 25.82
+	Hs
		642766 SART3_HUMAN (2-302): 1.67e-38: 146: 16.32		ELAV4_HUMAN (16-210): 6.97e-20: 93.7: 16.92
+	Hs
		1132324 RFOX1_HUMAN (37-267): 2.95e-31: 122: 12.39		CELF3_HUMAN (226-309): 4.05e-19: 92.2: 26.19
+	Hs
		198923 RFOX2_HUMAN (44-274): 2.32e-31: 122: 13.25		RBM23_HUMAN (113-300): 2.1e-16: 83.6: 26.60
+	Sc
		376958 NCBP2_YEAST (127-236): 1.25e-33: 124: 25.46		PABP_YEAST (465-553): 7.06e-12: 69.9: 16.85
+	Hs
		516744 PPIE_HUMAN (159-297): 4.41e-33: 125: 17.73		PABP1_HUMAN (457-550): 3.84e-10: 64.5: 10.64
+	Hs
		1031507 RBM8A_HUMAN (95-239): 7.02e-31: 115: 21.38		PABP4_HUMAN (457-550): 1.89e-10: 65.7: 10.64
+	Hs
		853881 NCBP2_HUMAN (128-271): 1.08e-30: 114: 18.06		PABP4_HUMAN (457-550): 1.89e-10: 65.7: 10.64
+	Hs
		516768 RBM8A_HUMAN (95-239): 7.02e-31: 115: 21.38		PABP1_HUMAN (457-550): 3.84e-10: 64.5: 10.64
+	Hs
		516425 NCBP2_HUMAN (128-271): 1.08e-30: 114: 18.06		PABP1_HUMAN (457-550): 3.84e-10: 64.5: 10.64