HitPredict

Interactor 1: RBBP5 (Q15291)
Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3)
Gene: RBBP5

Interactor 2: PAXI1 (Q6ZW49)
PAX-interacting protein 1 (PAX transactivation activation domain-interacting protein)
Gene: PAXIP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.746

Property	Details
Experiments	17925232, 17500065, 31076518, 24981860, 33961781, 23508102, 17178841
Identification Methods	affinity chromatography technology, biochemical, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0035097 - histone methyltransferase complex GO:0044666 - MLL3/4 complex
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 538 Hs			1 1069
+	Mm
		1157868 RBBP5_MOUSE (1-538): 9.56e-137: 408: 99.07		PAXI1_MOUSE (592-1069): 2.91e-144: 461: 92.47
+	Hs
		1070796 RBBP5_HUMAN (1-538): 2.69e-137: 410: 100.00		CHD7_HUMAN (188-893): 7.26e-34: 144: 9.07
+	Mm
		903666 WDR5_MOUSE (282-429): 2.1e-09: 61.2: 11.41		PAXI1_MOUSE (592-1069): 2.91e-144: 461: 92.47
+	Hs
		1070746 RBBP5_HUMAN (1-538): 2.69e-137: 410: 100.00		KMT2C_HUMAN (162-612): 3.03e-12: 73.5: 9.11
+	Hs
		1173233 WDR33_HUMAN (198-342): 2.09e-17: 88.1: 10.67		PAXI1_HUMAN (1-419): 4.99e-91: 316: 100.00
+	Hs
		1173203 FBXW7_HUMAN (279-521): 2.8e-16: 83.9: 10.56		PAXI1_HUMAN (1-419): 4.99e-91: 316: 100.00
+	Hs
		903325 WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41		PAXI1_HUMAN (1-419): 4.99e-91: 316: 100.00
+	Hs
		1056932 SNR40_HUMAN (229-467): 1.49e-19: 92: 9.59		MDC1_HUMAN (187-1069): 1.3e-57: 220: 14.77
+	Hs
		1056974 WDR33_HUMAN (198-342): 2.09e-17: 88.1: 10.67		MDC1_HUMAN (187-1069): 1.3e-57: 220: 14.77
+	Hs
		1288311 SNR40_HUMAN (229-467): 1.49e-19: 92: 9.59		ECT2_HUMAN (26-280): 1.93e-51: 198: 13.97
+	Hs
		1319412 WDR33_HUMAN (198-342): 2.09e-17: 88.1: 10.67		ECT2_HUMAN (26-280): 1.93e-51: 198: 13.97
+	Hs
		903526 WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41		ECT2_HUMAN (26-280): 1.93e-51: 198: 13.97
+	Dm
		1279330 EBI_DROME (179-518): 9.89e-30: 125: 10.98		Q9VUB7_DROME (7-621): 2.66e-29: 129: 19.38
+	Hs
		1266889 NLE1_HUMAN (2-135): 8.57e-34: 135: 18.38		TOPB1_HUMAN (3-336): 2.54e-18: 93.2: 16.86
+	Hs
		297832 BRWD3_HUMAN (228-450): 4.8e-15: 80.8: 12.86		K0754_HUMAN (205-737): 3.91e-29: 129: 7.83
+	Hs
		1281380 FBXW7_HUMAN (279-521): 2.8e-16: 83.9: 10.56		SIK2_HUMAN (258-632): 4.23e-25: 114: 19.26
+	Hs
		903374 WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41		KMT2C_HUMAN (162-612): 3.03e-12: 73.5: 9.11
+	Mm
		903669 WDR5_MOUSE (282-429): 2.1e-09: 61.2: 11.41		KMT2C_MOUSE (327-901): 7.84e-10: 65.8: 7.76