HitPredict

Interactor 1: RBBP5 (Q15291)
Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3)
Gene: RBBP5

Interactor 2: KMT2C (Q8NEZ4)
Histone-lysine N-methyltransferase 2C (Lysine N-methyltransferase 2C) (EC 2.1.1.364) (Homologous to ALR protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 3)
Gene: KMT2C

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	1.00	0.978

Property	Details
Experiments	12482968, 31076518, 24981860, 33961781, 23508102, 26324722, 27563068, 29785026, 30604749, 17500065, 26886794
Identification Methods	biochemical, affinity chromatography technology, pull down, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	association, physical association, direct interaction

Property	Details
Interacting Pfam domains	SET~WD40
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0035097 - histone methyltransferase complex GO:0042393 - histone binding GO:0044666 - MLL3/4 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 538 Hs			1 4911
+	Hs
		165680 RBBP5_HUMAN (1-538): 2.69e-137: 410: 100.00		SET1A_HUMAN (4638-4911): 3.38e-54: 214: 29.73
+	Dm
		1129085 RBBP5_DROME (1-494): 3.54e-103: 320: 65.79		SET1_DROME (4698-4911): 6.13e-60: 232: 34.57
+	Hs
		975258 RBBP5_HUMAN (1-538): 2.69e-137: 410: 100.00		KMT2A_HUMAN (159-332): 7.57e-32: 140: 22.16
+	Hs
		203735 DAW1_HUMAN (54-395): 7.21e-75: 244: 15.12		SUV91_HUMAN (4579-4910): 8.61e-90: 302: 19.18
+	Sc
		755771 SWD1_YEAST (1-356): 1.48e-77: 252: 30.08		SET1_YEAST (4555-4911): 4.81e-78: 286: 25.80
+	Hs
		1070809 RBBP5_HUMAN (1-538): 2.69e-137: 410: 100.00		SET1B_HUMAN (4778-4911): 3.56e-24: 115: 51.11
+	Sp
		194056 SWD1_SCHPO (1-392): 1.06e-88: 280: 32.68		SET1_SCHPO (4690-4911): 2.85e-63: 238: 37.82
+	Mm
		876680 RBBP5_MOUSE (1-538): 9.56e-137: 408: 99.07		KMT2A_MOUSE (1451-2373): 7.06e-12: 75.1: 10.84
+	Hs
		1070808 RBBP5_HUMAN (1-538): 2.69e-137: 410: 100.00		KMT2B_HUMAN (1985-2617): 4.3e-09: 65.8: 12.11
+	Hs
		152650 RBBP5_HUMAN (1-538): 2.69e-137: 410: 100.00		KMT2D_HUMAN (2766-3637): 7.14e-09: 65: 8.82
+	At
		1319861 WDR5A_ARATH (182-434): 2.41e-37: 142: 16.93		ATX1_ARATH (4688-4911): 9.07e-68: 254: 31.58
+	Hs
		331862 SNR40_HUMAN (229-467): 1.49e-19: 92: 9.59		NSD2_HUMAN (31-633): 2.18e-72: 272: 13.39
+	Hs
		1288292 SNR40_HUMAN (229-467): 1.49e-19: 92: 9.59		NSD3_HUMAN (1-668): 2.87e-64: 246: 13.52
+	Dm
		1129076 WDS_DROME (250-438): 1.02e-21: 98.5: 10.82		SET1_DROME (4698-4911): 6.13e-60: 232: 34.57
+	Hs
		1018714 NLE1_HUMAN (2-135): 8.57e-34: 135: 18.38		CHD3_HUMAN (390-526): 1.86e-31: 139: 21.38
+	Hs
		152663 WDR5B_HUMAN (2-225): 9.91e-62: 207: 16.88		KMT2D_HUMAN (2766-3637): 7.14e-09: 65: 8.82
+	Hs
		975304 SNR40_HUMAN (229-467): 1.49e-19: 92: 9.59		KMT2A_HUMAN (159-332): 7.57e-32: 140: 22.16
+	Hs
		1018633 SNR40_HUMAN (229-467): 1.49e-19: 92: 9.59		CHD3_HUMAN (390-526): 1.86e-31: 139: 21.38
+	Hs
		1288387 SNR40_HUMAN (229-467): 1.49e-19: 92: 9.59		KMT2B_HUMAN (1985-2617): 4.3e-09: 65.8: 12.11
+	Hs
		152678 FBXW7_HUMAN (279-521): 2.8e-16: 83.9: 10.56		KMT2D_HUMAN (2766-3637): 7.14e-09: 65: 8.82