HitPredict

Interactor 1: RBBP5 (Q15291)
Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3)
Gene: RBBP5

Interactor 2: SET1B (Q9UPS6)
Histone-lysine N-methyltransferase SETD1B (EC 2.1.1.364) (Lysine N-methyltransferase 2G) (SET domain-containing protein 1B) (hSET1B)
Gene: SETD1B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.972

Property	Details
Experiments	31076518, 24981860, 33961781, 23508102, 17355966, 26496610, 27563068, 29785026, 20516061
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	N-SET~WD40
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0035097 - histone methyltransferase complex GO:0048188 - Set1C/COMPASS complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 538 Hs			1 1966
+	Mm
		876680 RBBP5_MOUSE (1-538): 9.56e-137: 408: 99.07		KMT2A_MOUSE (1369-1966): 8.01e-74: 277: 24.76
+	Hs
		1070808 RBBP5_HUMAN (1-538): 2.69e-137: 410: 100.00		KMT2B_HUMAN (1069-1966): 4.68e-71: 268: 21.69
+	Hs
		975258 RBBP5_HUMAN (1-538): 2.69e-137: 410: 100.00		KMT2A_HUMAN (1173-1966): 2.68e-66: 252: 21.73
+	Hs
		1070746 RBBP5_HUMAN (1-538): 2.69e-137: 410: 100.00		KMT2C_HUMAN (1759-1966): 1.32e-58: 227: 37.04
+	Hs
		165680 RBBP5_HUMAN (1-538): 2.69e-137: 410: 100.00		SET1A_HUMAN (409-1966): 1e-54: 214: 22.13
+	Sp
		194056 SWD1_SCHPO (1-392): 1.06e-88: 280: 32.68		SET1_SCHPO (1461-1966): 2.02e-73: 267: 24.62
+	Dm
		1129085 RBBP5_DROME (1-494): 3.54e-103: 320: 65.79		SET1_DROME (30-197): 5.94e-53: 208: 38.60
+	Sc
		755771 SWD1_YEAST (1-356): 1.48e-77: 252: 30.08		SET1_YEAST (1532-1966): 8.55e-67: 250: 27.37
+	Hs
		152650 RBBP5_HUMAN (1-538): 2.69e-137: 410: 100.00		KMT2D_HUMAN (1826-1966): 3.07e-17: 91.3: 46.85
+	Hs
		203735 DAW1_HUMAN (54-395): 7.21e-75: 244: 15.12		SUV91_HUMAN (1686-1965): 2.95e-70: 244: 17.93
+	Zm
		35725 A0A1D6LQJ4_MAIZE (100-413): 7.31e-51: 179: 9.66		A0A1D6M742_MAIZE (1624-1963): 4.63e-62: 228: 17.44
+	At
		1319861 WDR5A_ARATH (182-434): 2.41e-37: 142: 16.93		ATX1_ARATH (1710-1966): 8.45e-64: 240: 31.03
+	Hs
		1288387 SNR40_HUMAN (229-467): 1.49e-19: 92: 9.59		KMT2B_HUMAN (1069-1966): 4.68e-71: 268: 21.69
+	Hs
		1317584 NLE1_HUMAN (2-135): 8.57e-34: 135: 18.38		SETD2_HUMAN (1733-1965): 3.5e-58: 225: 24.07
+	Hs
		1288292 SNR40_HUMAN (229-467): 1.49e-19: 92: 9.59		NSD3_HUMAN (1721-1965): 3.64e-68: 256: 24.90
+	Hs
		975304 SNR40_HUMAN (229-467): 1.49e-19: 92: 9.59		KMT2A_HUMAN (1173-1966): 2.68e-66: 252: 21.73
+	Hs
		331862 SNR40_HUMAN (229-467): 1.49e-19: 92: 9.59		NSD2_HUMAN (1654-1965): 6.33e-60: 230: 22.15
+	Hs
		1288291 SNR40_HUMAN (229-467): 1.49e-19: 92: 9.59		SETD2_HUMAN (1733-1965): 3.5e-58: 225: 24.07
+	Dm
		1129076 WDS_DROME (250-438): 1.02e-21: 98.5: 10.82		SET1_DROME (30-197): 5.94e-53: 208: 38.60
+	Hs
		152663 WDR5B_HUMAN (2-225): 9.91e-62: 207: 16.88		KMT2D_HUMAN (1826-1966): 3.07e-17: 91.3: 46.85