HitPredict

Interactor 1: RBBP5 (Q15291)
Retinoblastoma-binding protein 5 (RBBP-5) (Retinoblastoma-binding protein RBQ-3)
Gene: RBBP5

Interactor 2: HCFC2 (Q9Y5Z7)
Host cell factor 2 (HCF-2) (C2 factor)
Gene: HCFC2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	0.60	0.729

Property	Details
Experiments	28514442, 15199122, 33961781, 31076518, 24981860, 23508102
Identification Methods	affinity chromatography technology, biochemical, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0035097 - histone methyltransferase complex GO:0044665 - MLL1/2 complex GO:0048188 - Set1C/COMPASS complex and 1 others more... GO:0071339 - MLL1 complex
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 538 Hs			1 792
+	Hs
		903651 WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41		HCFC2_HUMAN (1-792): 0: 767: 100.00
+	Hs
		848222 RBBP5_HUMAN (1-538): 2.69e-137: 410: 100.00		HCFC1_HUMAN (513-789): 6.49e-98: 336: 42.81
+	Hs
		848181 WDR5_HUMAN (282-429): 2.1e-09: 61.2: 11.41		HCFC1_HUMAN (513-789): 6.49e-98: 336: 42.81
+	Dm
		1358847 WDS_DROME (250-438): 1.02e-21: 98.5: 10.82		HCF_DROME (416-784): 6.61e-85: 297: 30.69
+	Zm
		4796 A0A1D6DT61_MAIZE (4-301): 3.47e-65: 228: 21.36		A0A1D6P2L3_MAIZE (168-485): 3.81e-25: 113: 18.18
+	Hs
		1049312 WDR83_HUMAN (1-327): 4.72e-39: 146: 20.61		KEAP1_HUMAN (135-472): 1.42e-49: 186: 10.79
+	Sp
		953277 COPA_SCHPO (2-355): 1.35e-38: 153: 9.76		TEA1_SCHPO (3-170): 6.97e-29: 126: 26.04
+	Hs
		1049297 SNR40_HUMAN (229-467): 1.49e-19: 92: 9.59		KEAP1_HUMAN (135-472): 1.42e-49: 186: 10.79
+	Hs
		1159438 WDR33_HUMAN (198-342): 2.09e-17: 88.1: 10.67		FBX42_HUMAN (184-356): 8.06e-10: 64.3: 29.05