HitPredict

Interactor 1: ERBB4 (Q15303)
Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)]
Gene: ERBB4

Interactor 2: LRIG3 (Q6UXM1)
Leucine-rich repeats and immunoglobulin-like domains protein 3 (LIG-3)
Gene: LRIG3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	20126551
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	GF_recep_IV~LRR_8, LRR_8~PK_Tyr_Ser-Thr
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1308 Hs			1 1119
+	Hs
		383860 ERBB2_HUMAN (25-1272): 0: 1090: 46.29		LRIG3_HUMAN (2-1119): 0: 769: 100.00
+	Hs
		338583 EGFR_HUMAN (20-1286): 0: 1039: 48.70		LRIG3_HUMAN (2-1119): 0: 769: 100.00
+	Hs
		1070999 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		LRIG1_HUMAN (1-187): 2.9e-16: 86.4: 14.98
+	Mm
		936212 EGFR_MOUSE (21-1286): 0: 1089: 49.53		LRIG1_MOUSE (2-697): 2.26e-97: 335: 19.89
+	Hs
		601975 ERBB3_HUMAN (1-1258): 0: 1094: 47.33		LRIG1_HUMAN (1-187): 2.9e-16: 86.4: 14.98
+	Hs
		299545 EGFR_HUMAN (20-1286): 0: 1039: 48.70		LRIG2_HUMAN (773-1091): 2.37e-33: 141: 12.05
+	Hs
		383933 ERBB2_HUMAN (25-1272): 0: 1090: 46.29		LRIG1_HUMAN (1-187): 2.9e-16: 86.4: 14.98
+	Hs
		338833 EGFR_HUMAN (20-1286): 0: 1039: 48.70		LIGO1_HUMAN (311-786): 7.13e-32: 134: 17.66
+	Mm
		964570 EGFR_MOUSE (21-1286): 0: 1089: 49.53		LIGO1_MOUSE (701-786): 1.49e-12: 73.7: 23.86
+	Hs
		338841 EGFR_HUMAN (20-1286): 0: 1039: 48.70		LRIG1_HUMAN (1-187): 2.9e-16: 86.4: 14.98
+	At
		83408 Y1684_ARATH (250-1032): 7.72e-146: 468: 16.14		ERECT_ARATH (1-610): 7.14e-111: 371: 16.86
+	At
		1114685 ERL2_ARATH (331-1008): 6.2e-138: 448: 14.12		ERECT_ARATH (1-610): 7.14e-111: 371: 16.86
+	At
		83401 Y1684_ARATH (250-1032): 7.72e-146: 468: 16.14		GSO1_ARATH (24-569): 7.63e-88: 311: 18.66
+	At
		85353 ERL2_ARATH (331-1008): 6.2e-138: 448: 14.12		ERL1_ARATH (1-402): 3.91e-85: 299: 21.21
+	At
		186962 ERL2_ARATH (331-1008): 6.2e-138: 448: 14.12		BRI1_ARATH (80-545): 3.23e-70: 258: 21.67
+	At
		83411 Y1684_ARATH (250-1032): 7.72e-146: 468: 16.14		ERL2_ARATH (176-565): 1.93e-55: 211: 15.82
+	At
		85103 ERL2_ARATH (331-1008): 6.2e-138: 448: 14.12		RGI2_ARATH (4-262): 1.77e-45: 181: 22.47
+	At
		83404 Y1684_ARATH (250-1032): 7.72e-146: 468: 16.14		RGI4_ARATH (6-197): 1.41e-26: 119: 21.36
+	At
		84594 ERL2_ARATH (331-1008): 6.2e-138: 448: 14.12		RGI3_ARATH (216-458): 2.47e-31: 135: 21.51
+	At
		99012 ERL2_ARATH (331-1008): 6.2e-138: 448: 14.12		RGI4_ARATH (6-197): 1.41e-26: 119: 21.36