HitPredict

Interactor 1: ERBB4 (Q15303)
Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)]
Gene: ERBB4

Interactor 2: TENS4 (Q8IZW8)
Tensin-4 (C-terminal tensin-like protein)
Gene: TNS4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	22973453
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1308 Hs			1 715
+	Hs
		1070975 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		TENS3_HUMAN (1-714): 7.94e-77: 271: 26.80
+	Hs
		1070974 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		TENS2_HUMAN (129-714): 2.06e-70: 252: 30.86
+	Hs
		1071015 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		TENS1_HUMAN (9-712): 2.82e-68: 246: 29.79
+	Hs
		522997 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		SRC_HUMAN (287-582): 1.42e-21: 100: 14.56
+	Hs
		1071013 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		SLAP2_HUMAN (399-601): 2.94e-21: 95.9: 22.22
+	Hs
		554307 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		MUC1_HUMAN (165-615): 4.13e-17: 88.3: 9.03
+	Hs
		1028470 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		SLAP1_HUMAN (382-578): 2.29e-16: 82: 17.70
+	Hs
		601945 ERBB3_HUMAN (1-1258): 0: 1094: 47.33		TENS4_HUMAN (1-715): 2.96e-94: 309: 100.00
+	Hs
		601935 ERBB3_HUMAN (1-1258): 0: 1094: 47.33		TENS3_HUMAN (1-714): 7.94e-77: 271: 26.80
+	Hs
		601934 ERBB3_HUMAN (1-1258): 0: 1094: 47.33		TENS2_HUMAN (129-714): 2.06e-70: 252: 30.86
+	Hs
		383851 ERBB2_HUMAN (25-1272): 0: 1090: 46.29		TENS2_HUMAN (129-714): 2.06e-70: 252: 30.86
+	Hs
		602002 ERBB3_HUMAN (1-1258): 0: 1094: 47.33		TENS1_HUMAN (9-712): 2.82e-68: 246: 29.79
+	Rn
		1225226 Q8K3F9_RAT (6-1272): 0: 1096: 44.95		SRC_RAT (287-582): 3.16e-22: 103: 14.56
+	Hs
		522774 ERBB3_HUMAN (1-1258): 0: 1094: 47.33		SRC_HUMAN (287-582): 1.42e-21: 100: 14.56
+	Hs
		383570 ERBB2_HUMAN (25-1272): 0: 1090: 46.29		SRC_HUMAN (287-582): 1.42e-21: 100: 14.56
+	Hs
		601998 ERBB3_HUMAN (1-1258): 0: 1094: 47.33		SLAP2_HUMAN (399-601): 2.94e-21: 95.9: 22.22
+	Hs
		554266 ERBB3_HUMAN (1-1258): 0: 1094: 47.33		MUC1_HUMAN (165-615): 4.13e-17: 88.3: 9.03
+	Hs
		383583 ERBB2_HUMAN (25-1272): 0: 1090: 46.29		MUC1_HUMAN (165-615): 4.13e-17: 88.3: 9.03
+	Hs
		601910 ERBB3_HUMAN (1-1258): 0: 1094: 47.33		SLAP1_HUMAN (382-578): 2.29e-16: 82: 17.70
+	Hs
		383777 ERBB2_HUMAN (25-1272): 0: 1090: 46.29		SLAP1_HUMAN (382-578): 2.29e-16: 82: 17.70