HitPredict

Interactor 1: ERBB4 (Q15303)
Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)]
Gene: ERBB4

Interactor 2: DUS21 (Q9H596)
Dual specificity protein phosphatase 21 (EC 3.1.3.16) (EC 3.1.3.48) (Low molecular weight dual specificity phosphatase 21) (LMW-DSP21)
Gene: DUSP21

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	28065597
Identification Methods	two hybrid, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005759 - mitochondrial matrix
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1308 Hs			1 190
+	Hs
		304961 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		DUS14_HUMAN (7-189): 5.03e-80: 238: 45.90
+	Hs
		1070986 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		DUS18_HUMAN (1-190): 5.63e-77: 230: 68.95
+	Hs
		1071007 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		DUS16_HUMAN (6-190): 1.18e-68: 222: 28.21
+	Hs
		1070972 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		DUS6_HUMAN (3-160): 6.08e-66: 208: 25.63
+	Hs
		1071034 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		DUS10_HUMAN (2-179): 4.82e-58: 190: 28.89
+	Hs
		1070988 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		DUS19_HUMAN (25-173): 1.51e-60: 189: 30.87
+	Hs
		1070989 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		STYX_HUMAN (3-171): 1.11e-59: 187: 25.42
+	Hs
		304917 ERBB3_HUMAN (1-1258): 0: 1094: 47.33		DUS14_HUMAN (7-189): 5.03e-80: 238: 45.90
+	Hs
		304905 ERBB2_HUMAN (25-1272): 0: 1090: 46.29		DUS14_HUMAN (7-189): 5.03e-80: 238: 45.90
+	Hs
		601951 ERBB3_HUMAN (1-1258): 0: 1094: 47.33		DUS18_HUMAN (1-190): 5.63e-77: 230: 68.95
+	Hs
		383888 ERBB2_HUMAN (25-1272): 0: 1090: 46.29		DUS18_HUMAN (1-190): 5.63e-77: 230: 68.95
+	Hs
		601997 ERBB3_HUMAN (1-1258): 0: 1094: 47.33		DUS21_HUMAN (1-190): 1.14e-73: 221: 100.00
+	Hs
		383901 ERBB2_HUMAN (25-1272): 0: 1090: 46.29		SSH1_HUMAN (18-190): 1.35e-63: 213: 24.74
+	Hs
		601956 ERBB3_HUMAN (1-1258): 0: 1094: 47.33		DUS19_HUMAN (25-173): 1.51e-60: 189: 30.87
+	Hs
		601957 ERBB3_HUMAN (1-1258): 0: 1094: 47.33		STYX_HUMAN (3-171): 1.11e-59: 187: 25.42
+	Hs
		383896 ERBB2_HUMAN (25-1272): 0: 1090: 46.29		DUS19_HUMAN (25-173): 1.51e-60: 189: 30.87
+	Hs
		304901 EGFR_HUMAN (20-1286): 0: 1039: 48.70		DUS14_HUMAN (7-189): 5.03e-80: 238: 45.90
+	Hs
		383897 ERBB2_HUMAN (25-1272): 0: 1090: 46.29		STYX_HUMAN (3-171): 1.11e-59: 187: 25.42
+	Hs
		601936 ERBB3_HUMAN (1-1258): 0: 1094: 47.33		DUS29_HUMAN (16-160): 3.1e-55: 175: 29.41
+	Hs
		338145 EGFR_HUMAN (20-1286): 0: 1039: 48.70		DUS3_HUMAN (7-167): 3.14e-55: 174: 27.49