HitPredict

Interactor 1: ERBB4 (Q15303)
Receptor tyrosine-protein kinase erbB-4 (EC 2.7.10.1) (Proto-oncogene-like protein c-ErbB-4) (Tyrosine kinase-type cell surface receptor HER4) (p180erbB4) [Cleaved into: ERBB4 intracellular domain (4ICD) (E4ICD) (s80HER4)]
Gene: ERBB4

Interactor 2: SH2B1 (Q9NRF2)
SH2B adapter protein 1 (Pro-rich, PH and SH2 domain-containing signaling mediator) (PSM) (SH2 domain-containing protein 1B)
Gene: SH2B1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	22973453
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1308 Hs			1 756
+	Hs
		145979 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		SH2B2_HUMAN (25-755): 5.52e-128: 396: 35.11
+	Hs
		1070976 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		SHC4_HUMAN (81-631): 1.06e-100: 325: 17.68
+	Hs
		666116 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		SHC1_HUMAN (52-627): 2.87e-100: 322: 17.54
+	Hs
		1031667 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		GRB10_HUMAN (82-618): 1.38e-92: 302: 12.05
+	Hs
		548711 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		VAV_HUMAN (40-685): 2.92e-87: 295: 13.46
+	Hs
		1070990 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		SHC3_HUMAN (80-629): 3.43e-88: 291: 15.73
+	Hs
		1054054 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		GRB7_HUMAN (99-613): 1.08e-80: 269: 12.89
+	Hs
		957124 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		SHC2_HUMAN (94-629): 5.86e-77: 261: 15.22
+	Hs
		433359 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		YES_HUMAN (356-742): 4.3e-76: 257: 14.25
+	Hs
		412202 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		FYN_HUMAN (401-742): 2.99e-74: 252: 13.87
+	Hs
		581010 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		PLCG1_HUMAN (451-753): 3.41e-69: 249: 17.19
+	Hs
		1071028 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		SH2B3_HUMAN (340-754): 1.95e-72: 248: 30.12
+	Hs
		442833 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		HCK_HUMAN (378-742): 6.58e-73: 248: 15.57
+	Hs
		522997 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		SRC_HUMAN (376-742): 1.26e-71: 245: 13.88
+	Hs
		454834 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		FGR_HUMAN (401-742): 5.95e-70: 240: 14.75
+	Hs
		411729 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		LCK_HUMAN (435-742): 9.33e-67: 231: 17.13
+	Hs
		562648 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		PLCG2_HUMAN (507-753): 4.8e-47: 183: 17.11
+	Hs
		788965 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		MATK_HUMAN (439-604): 3.53e-23: 105: 21.18
+	Hs
		796580 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		KSYK_HUMAN (526-637): 4.25e-17: 87.5: 23.01
+	Hs
		924589 ERBB4_HUMAN (1-1308): 0: 1406: 100.00		GRB2_HUMAN (517-646): 2.75e-16: 80.5: 18.46