HitPredict

Interactor 1: ZMY11 (Q15326)
Zinc finger MYND domain-containing protein 11 (Adenovirus 5 E1A-binding protein) (Bone morphogenetic protein receptor-associated molecule 1) (Protein BS69)
Gene: ZMYND11

Interactor 2: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	16565076
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003714 - transcription corepressor activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006325 - chromatin organization GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 602 Hs			1 746
+	Hs
		1071484 ZMY11_HUMAN (1-602): 0: 607: 100.00		EZH1_HUMAN (15-745): 0: 745: 63.48
+	Hs
		1080481 TRI33_HUMAN (57-304): 9.89e-41: 160: 16.67		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		1080295 CECR2_HUMAN (123-470): 2.1e-38: 154: 12.26		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		1080191 KAT2B_HUMAN (122-254): 2.57e-31: 131: 17.78		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		1029465 TIF1B_HUMAN (76-254): 7.94e-31: 130: 14.29		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		1080166 PHIP_HUMAN (123-555): 1.6e-23: 108: 10.97		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		975259 ZMY11_HUMAN (1-602): 0: 607: 100.00		KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54
+	Hs
		164474 TRI66_HUMAN (75-309): 3.16e-43: 168: 18.35		SETD2_HUMAN (190-732): 2.07e-89: 310: 16.64
+	Dm
		532755 FSH_DROME (128-259): 2.76e-29: 126: 15.56		ASH1_DROME (196-732): 2.08e-99: 339: 18.55
+	Hs
		1315219 CECR2_HUMAN (123-470): 2.1e-38: 154: 12.26		SETD2_HUMAN (190-732): 2.07e-89: 310: 16.64
+	Hs
		1317590 BRPF3_HUMAN (127-549): 2.26e-38: 154: 14.13		SETD2_HUMAN (190-732): 2.07e-89: 310: 16.64
+	Hs
		331804 TIF1B_HUMAN (76-254): 7.94e-31: 130: 14.29		NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03
+	Hs
		1029886 TIF1B_HUMAN (76-254): 7.94e-31: 130: 14.29		EHMT1_HUMAN (441-732): 1.73e-70: 253: 24.27
+	Hs
		1271486 KAT2B_HUMAN (122-254): 2.57e-31: 131: 17.78		EHMT2_HUMAN (467-732): 1.91e-68: 247: 24.21
+	Hs
		1029752 TIF1B_HUMAN (76-254): 7.94e-31: 130: 14.29		EHMT2_HUMAN (467-732): 1.91e-68: 247: 24.21
+	Hs
		203676 TIF1B_HUMAN (76-254): 7.94e-31: 130: 14.29		SUV91_HUMAN (354-731): 2.25e-71: 240: 19.90
+	Hs
		1344270 BRPF3_HUMAN (127-549): 2.26e-38: 154: 14.13		ASH1L_HUMAN (547-732): 3.87e-57: 214: 30.85
+	Sc
		810355 GCN5_YEAST (128-256): 7.23e-33: 133: 16.15		SET2_YEAST (470-733): 1.22e-59: 216: 25.56
+	Hs
		165672 TIF1B_HUMAN (76-254): 7.94e-31: 130: 14.29		SET1A_HUMAN (611-732): 3.19e-18: 92: 38.71
+	Hs
		600130 TAF1_HUMAN (129-459): 1.13e-24: 111: 12.20		KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54