HitPredict

Interactor 1: ANKR1 (Q15327)
Ankyrin repeat domain-containing protein 1 (Cardiac ankyrin repeat protein) (Cytokine-inducible gene C-193 protein) (Cytokine-inducible nuclear protein)
Gene: ANKRD1

Interactor 2: TITIN (Q8WZ42)
Titin (EC 2.7.11.1) (Connectin) (Rhabdomyosarcoma antigen MU-RMS-40.14)
Gene: TTN

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.812

Property	Details
Experiments	14583192, 23414517
Identification Methods	two hybrid, pull down, two hybrid fragment pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Ank_2~fn3, Ank_2~I-set, Ank_2~Pkinase
Common GO terms	GO:0005829 - cytosol GO:0031674 - I band GO:0045214 - sarcomere organization GO:0050714 - positive regulation of protein secretion GO:0055008 - cardiac muscle tissue morphogenesis
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 319 Hs			1 34350
+	Hs
		1197627 ANR23_HUMAN (78-305): 2.93e-75: 235: 47.19		TITIN_HUMAN (1-34350): 0: 28064: 100.00
+	Hs
		1264800 ANKR2_HUMAN (28-300): 3.46e-69: 221: 46.89		TITIN_HUMAN (1-34350): 0: 28064: 100.00
+	Hs
		166985 ANR28_HUMAN (109-317): 1.78e-43: 161: 20.09		TITIN_HUMAN (1-34350): 0: 28064: 100.00
+	Hs
		556716 ANK1_HUMAN (3-172): 6.78e-29: 119: 12.94		TITIN_HUMAN (1-34350): 0: 28064: 100.00
+	Hs
		1115387 AKD1A_HUMAN (126-289): 3.01e-09: 59.7: 26.79		TITIN_HUMAN (1-34350): 0: 28064: 100.00
+	Hs
		363344 KDIS_HUMAN (5-222): 1.62e-40: 152: 14.46		FINC_HUMAN (26307-28070): 3.11e-129: 464: 16.42
+	Mm
		1207301 ANKR1_MOUSE (1-319): 5.74e-79: 244: 90.28		Q8BUJ0_MOUSE (31729-32201): 3.78e-50: 202: 22.89
+	Dm
		65570 A8JNM5_DROME (5-139): 3.18e-12: 69.5: 6.67		FUTSC_DROME (10093-12075): 1.26e-78: 299: 16.27
+	Hs
		234570 PP16B_HUMAN (64-212): 5.75e-13: 71.1: 18.75		DSCAM_HUMAN (31163-32191): 1.5e-76: 291: 15.23
+	Hs
		869994 ANKR1_HUMAN (1-319): 4.86e-86: 262: 100.00		MYOM2_HUMAN (2901-3346): 3.69e-09: 68.6: 21.30
+	Hs
		962506 ANKR1_HUMAN (1-319): 4.86e-86: 262: 100.00		MYPC1_HUMAN (15875-16031): 5.27e-09: 68.2: 26.67
+	Mm
		57587 ANKR1_MOUSE (1-319): 5.74e-79: 244: 90.28		TITIN_MOUSE (5223-5317): 8.37e-10: 71.2: 24.49
+	Hs
		965118 ANK2_HUMAN (85-316): 6.6e-63: 217: 20.07		OBSCN_HUMAN (30666-30849): 2.08e-16: 92.7: 24.32
+	Hs
		166900 ANR28_HUMAN (109-317): 1.78e-43: 161: 20.09		MYOM1_HUMAN (6461-6928): 1.38e-09: 70.1: 21.15
+	Hs
		556706 ANK1_HUMAN (3-172): 6.78e-29: 119: 12.94		OBSCN_HUMAN (30666-30849): 2.08e-16: 92.7: 24.32
+	Hs
		870002 EHMT2_HUMAN (5-205): 3.75e-25: 108: 14.55		MYOM2_HUMAN (2901-3346): 3.69e-09: 68.6: 21.30