HitPredict

Interactor 1: L2GL1 (Q15334)
Lethal(2) giant larvae protein homolog 1 (LLGL) (DLG4) (Hugl-1) (Human homolog to the D-lgl gene protein)
Gene: LLGL1

Interactor 2: PAR6B (Q9BYG5)
Partitioning defective 6 homolog beta (PAR-6 beta) (PAR-6B)
Gene: PARD6B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.90	0.60	0.735

Property	Details
Experiments	26496610, 26186194, 28514442, 33961781, 14676191, 24366813
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007409 - axonogenesis GO:0045197 - establishment or maintenance of epithelial cell apical/basal polarity GO:0065003 - protein-containing complex assembly
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 1064 Hs			1 372
+	Hs
		1071567 L2GL1_HUMAN (1-1064): 0: 1391: 100.00		PAR6G_HUMAN (1-372): 3.55e-126: 369: 54.73
+	Hs
		1071578 L2GL1_HUMAN (1-1064): 0: 1391: 100.00		PAR6A_HUMAN (1-325): 8.79e-92: 280: 53.37
+	Hs
		1158573 L2GL2_HUMAN (5-979): 0: 1216: 56.97		PAR6B_HUMAN (1-372): 2.86e-151: 433: 100.00
+	Mm
		1194470 L2GL1_MOUSE (1-1039): 0: 1350: 90.57		PAR6A_MOUSE (1-330): 1.1e-95: 290: 52.07
+	Hs
		1158572 L2GL2_HUMAN (5-979): 0: 1216: 56.97		PAR6G_HUMAN (1-372): 3.55e-126: 369: 54.73
+	Hs
		1158580 L2GL2_HUMAN (5-979): 0: 1216: 56.97		PAR6A_HUMAN (1-325): 8.79e-92: 280: 53.37
+	Dm
		332594 L2GL_DROME (1-1041): 0: 984: 35.51		O97111_DROME (7-297): 1.98e-90: 277: 53.74
+	Ce
		106869 G5EEI1_CAEEL (4-941): 0: 810: 20.57		PAR6_CAEEL (4-273): 2.54e-89: 273: 52.19