HitPredict

Interactor 1: PCBP1 (Q15365)
Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) (Nucleic acid-binding protein SUB2.3)
Gene: PCBP1

Interactor 2: IF2B2 (Q9Y6M1)
Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2 mRNA-binding protein 2) (IMP-2) (Hepatocellular carcinoma autoantigen p62) (IGF-II mRNA-binding protein 2) (VICKZ family member 2)
Gene: IGF2BP2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	27684187, 29395067
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	KH_1~KH_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 356 Hs			1 599
+	Mm
		888809 PCBP1_MOUSE (1-356): 2.47e-107: 320: 100.00		IF2B2_MOUSE (1-599): 6.75e-148: 441: 93.49
+	Hs
		1072219 PCBP2_HUMAN (1-352): 1.2e-97: 295: 81.44		IF2B2_HUMAN (1-599): 1.06e-146: 438: 100.00
+	Hs
		128188 PCBP1_HUMAN (1-356): 2.47e-107: 320: 100.00		IF2B3_HUMAN (2-599): 4.89e-134: 405: 62.36
+	Hs
		1072046 PCBP1_HUMAN (1-356): 2.47e-107: 320: 100.00		IF2B1_HUMAN (2-599): 2.29e-130: 395: 63.89
+	Hs
		1072196 PCBP2_HUMAN (1-352): 1.2e-97: 295: 81.44		IF2B1_HUMAN (2-599): 2.29e-130: 395: 63.89
+	Mm
		291665 HNRPK_MOUSE (7-353): 1.94e-68: 223: 22.51		IF2B1_MOUSE (2-599): 8.33e-131: 397: 63.56
+	Hs
		884308 PCBP1_HUMAN (1-356): 2.47e-107: 320: 100.00		PCBP3_HUMAN (385-597): 7.22e-39: 148: 24.31
+	Hs
		1071870 PCBP1_HUMAN (1-356): 2.47e-107: 320: 100.00		PCBP2_HUMAN (422-597): 7.25e-36: 140: 26.92
+	Hs
		884309 PCBP2_HUMAN (1-352): 1.2e-97: 295: 81.44		PCBP3_HUMAN (385-597): 7.22e-39: 148: 24.31
+	Hs
		1072094 PCBP2_HUMAN (1-352): 1.2e-97: 295: 81.44		PCBP2_HUMAN (422-597): 7.25e-36: 140: 26.92
+	Mm
		888806 PCBP1_MOUSE (1-356): 2.47e-107: 320: 100.00		Q3TIX6_MOUSE (196-414): 2.2e-19: 94.1: 17.62
+	Mm
		888797 PCBP1_MOUSE (1-356): 2.47e-107: 320: 100.00		HNRPK_MOUSE (386-596): 5.84e-18: 88.9: 17.09
+	Hs
		903947 PCBP1_HUMAN (1-356): 2.47e-107: 320: 100.00		HNRPK_HUMAN (386-596): 5.84e-18: 88.9: 17.09
+	Hs
		884381 PCBP1_HUMAN (1-356): 2.47e-107: 320: 100.00		PCBP4_HUMAN (183-385): 2.13e-15: 80.4: 17.11
+	Hs
		959431 PCBP1_HUMAN (1-356): 2.47e-107: 320: 100.00		VIGLN_HUMAN (444-585): 4.33e-12: 71.5: 19.01
+	Hs
		1071869 PCBP1_HUMAN (1-356): 2.47e-107: 320: 100.00		PCBP1_HUMAN (422-530): 8.21e-11: 65.8: 25.69
+	Hs
		903948 PCBP2_HUMAN (1-352): 1.2e-97: 295: 81.44		HNRPK_HUMAN (386-596): 5.84e-18: 88.9: 17.09
+	Mm
		904265 PCBP2_MOUSE (1-352): 8.56e-95: 288: 79.28		HNRPK_MOUSE (386-596): 5.84e-18: 88.9: 17.09
+	Hs
		959432 PCBP2_HUMAN (1-352): 1.2e-97: 295: 81.44		VIGLN_HUMAN (444-585): 4.33e-12: 71.5: 19.01