HitPredict

Interactor 1: ELOC (Q15369)
Elongin-C (EloC) (Elongin 15 kDa subunit) (RNA polymerase II transcription factor SIII subunit C) (SIII p15) (Transcription elongation factor B polypeptide 1)
Gene: ELOC

Interactor 2: SPSB1 (Q96BD6)
SPRY domain-containing SOCS box protein 1 (SSB-1)
Gene: SPSB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.849

Property	Details
Experiments	21199876, 19159283, 15601820
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	SOCS_box~Skp1_POZ
Common GO terms	GO:0005829 - cytosol GO:0006511 - ubiquitin-dependent protein catabolic process GO:0016567 - protein ubiquitination
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 112 Hs			1 273
+	Hs
		1072273 ELOC_HUMAN (1-112): 2.74e-68: 202: 100.00		SPSB4_HUMAN (1-273): 1.02e-119: 345: 74.73
+	Dm
		51273 Q7JWD6_DROME (1-112): 1.74e-67: 200: 90.35		GUS_DROME (1-273): 2.52e-114: 331: 69.57
+	Hs
		1072293 ELOC_HUMAN (1-112): 2.74e-68: 202: 100.00		SPSB2_HUMAN (1-273): 3.23e-94: 280: 50.18
+	Dm
		1177546 Q7JWD6_DROME (1-112): 1.74e-67: 200: 90.35		Q9VMV3_DROME (41-265): 8.8e-61: 196: 29.31
+	Hs
		1072240 ELOC_HUMAN (1-112): 2.74e-68: 202: 100.00		SPSB3_HUMAN (54-270): 5.39e-59: 193: 25.11
+	Hs
		1072242 ELOC_HUMAN (1-112): 2.74e-68: 202: 100.00		TRI67_HUMAN (52-232): 7.58e-36: 137: 17.11