HitPredict

Interactor 1: RHEB (Q15382)
GTP-binding protein Rheb (Ras homolog enriched in brain) (EC 3.6.5.-)
Gene: RHEB

Interactor 2: TSC1 (Q92574)
Hamartin (Tuberous sclerosis 1 protein)
Gene: TSC1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	30514904, 12820960
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005765 - lysosomal membrane GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0014069 - postsynaptic density GO:0016020 - membrane and 1 others more... GO:0051726 - regulation of cell cycle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 184 Hs			1 1164
+	Hs
		914256 RB11A_HUMAN (4-180): 7.77e-76: 228: 29.78		TSC1_HUMAN (1-1164): 0: 725: 100.00
+	Hs
		895211 RAB2A_HUMAN (1-170): 4.79e-74: 223: 31.58		TSC1_HUMAN (1-1164): 0: 725: 100.00
+	Mm
		898000 RAP2B_MOUSE (19-181): 1.59e-34: 121: 40.24		TSC1_MOUSE (1-1164): 0: 695: 86.98
+	Hs
		1079935 RB11B_HUMAN (4-180): 2.7e-75: 226: 30.34		Q86WV8_HUMAN (1-343): 3.4e-177: 526: 100.00
+	Hs
		894733 RAB8A_HUMAN (7-179): 4.93e-85: 251: 29.05		DCTN1_HUMAN (540-1022): 9.26e-59: 223: 16.33
+	Hs
		895077 RAB2A_HUMAN (1-170): 4.79e-74: 223: 31.58		DCTN1_HUMAN (540-1022): 9.26e-59: 223: 16.33
+	Hs
		254466 RB11A_HUMAN (4-180): 7.77e-76: 228: 29.78		ROCK2_HUMAN (415-1038): 1.55e-24: 113: 11.27
+	Hs
		148636 RAB1A_HUMAN (4-183): 1.28e-76: 229: 30.27		CTRO_HUMAN (337-991): 3.67e-23: 109: 7.78
+	Hs
		895213 RAB2A_HUMAN (1-170): 4.79e-74: 223: 31.58		MY18A_HUMAN (461-1064): 4e-25: 115: 10.31
+	Hs
		149274 RAB1B_HUMAN (4-173): 8.3e-76: 227: 30.41		CTRO_HUMAN (337-991): 3.67e-23: 109: 7.78
+	Hs
		254463 RAB2A_HUMAN (1-170): 4.79e-74: 223: 31.58		ROCK2_HUMAN (415-1038): 1.55e-24: 113: 11.27
+	Hs
		148551 RAB13_HUMAN (1-180): 8.32e-73: 219: 28.42		CTRO_HUMAN (337-991): 3.67e-23: 109: 7.78
+	Dm
		1303400 RHEB_DROME (1-183): 2.11e-75: 225: 63.93		MYSN_DROME (417-1038): 2.47e-19: 96.8: 9.88
+	Hs
		914124 RB11A_HUMAN (4-180): 7.77e-76: 228: 29.78		MRCKA_HUMAN (278-842): 4.78e-17: 89.1: 8.78
+	Hs
		895123 RAB2A_HUMAN (1-170): 4.79e-74: 223: 31.58		MRCKA_HUMAN (278-842): 4.78e-17: 89.1: 8.78
+	Hs
		895066 RAB2A_HUMAN (1-170): 4.79e-74: 223: 31.58		ROCK1_HUMAN (433-926): 6.18e-15: 82.2: 12.00
+	Hs
		914116 RB11A_HUMAN (4-180): 7.77e-76: 228: 29.78		CYTSB_HUMAN (740-1117): 1.86e-12: 74.1: 12.41
+	Dm
		1362781 RHEB_DROME (1-183): 2.11e-75: 225: 63.93		Q9VCC9_DROME (835-1160): 2.53e-09: 63.7: 9.76
+	Dm
		332202 O96692_DROME (19-166): 1.07e-30: 112: 38.51		Q8INC3_DROME (441-1011): 3.85e-23: 109: 11.72
+	Dm
		332193 O96692_DROME (19-166): 1.07e-30: 112: 38.51		Q0KI67_DROME (441-1011): 8.87e-23: 107: 11.72