HitPredict

Interactor 1: RHEB (Q15382)
GTP-binding protein Rheb (Ras homolog enriched in brain) (EC 3.6.5.-)
Gene: RHEB

Interactor 2: SRPRB (Q9Y5M8)
Signal recognition particle receptor subunit beta (SR-beta) (Protein APMCF1)
Gene: SRPRB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005525 - GTP binding GO:0005789 - endoplasmic reticulum membrane GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 184 Hs			1 271
+	Hs
		894719 RAB8A_HUMAN (7-179): 4.93e-85: 251: 29.05		ARF5_HUMAN (46-240): 5.42e-75: 227: 21.03
+	Hs
		894833 RAB8A_HUMAN (7-179): 4.93e-85: 251: 29.05		SRPRB_HUMAN (1-271): 4.47e-69: 216: 100.00
+	Hs
		913034 RAB8B_HUMAN (7-180): 2.12e-85: 251: 29.55		ARF6_HUMAN (60-239): 5.9e-70: 215: 20.00
+	Hs
		914005 RB11A_HUMAN (4-180): 7.77e-76: 228: 29.78		ARF5_HUMAN (46-240): 5.42e-75: 227: 21.03
+	Hs
		894715 RAB8A_HUMAN (7-179): 4.93e-85: 251: 29.05		RAB1A_HUMAN (54-265): 1.14e-63: 200: 14.49
+	Hs
		574637 RAB8A_HUMAN (7-179): 4.93e-85: 251: 29.05		ARF4_HUMAN (46-240): 2.72e-63: 198: 20.51
+	Hs
		894718 RAB8A_HUMAN (7-179): 4.93e-85: 251: 29.05		ARF1_HUMAN (46-240): 2.73e-62: 195: 21.54
+	Hs
		912837 RAB1A_HUMAN (4-183): 1.28e-76: 229: 30.27		ARF6_HUMAN (60-239): 5.9e-70: 215: 20.00
+	Hs
		914492 RB11A_HUMAN (4-180): 7.77e-76: 228: 29.78		SRPRB_HUMAN (1-271): 4.47e-69: 216: 100.00
+	Hs
		912835 RB11A_HUMAN (4-180): 7.77e-76: 228: 29.78		ARF6_HUMAN (60-239): 5.9e-70: 215: 20.00
+	Hs
		913100 RAB1B_HUMAN (4-173): 8.3e-76: 227: 30.41		ARF6_HUMAN (60-239): 5.9e-70: 215: 20.00
+	Zm
		73944 B4FAE1_MAIZE (4-180): 3.37e-79: 236: 31.46		B4FAE1_MAIZE (57-268): 6.81e-65: 203: 12.84
+	Hs
		918846 RAB1A_HUMAN (4-183): 1.28e-76: 229: 30.27		RAB1A_HUMAN (54-265): 1.14e-63: 200: 14.49
+	Hs
		918916 RAB2B_HUMAN (1-170): 1.32e-76: 229: 30.41		RAB1A_HUMAN (54-265): 1.14e-63: 200: 14.49
+	Hs
		913992 RB11A_HUMAN (4-180): 7.77e-76: 228: 29.78		RAB1A_HUMAN (54-265): 1.14e-63: 200: 14.49
+	Hs
		918944 RAB1B_HUMAN (4-173): 8.3e-76: 227: 30.41		RAB1A_HUMAN (54-265): 1.14e-63: 200: 14.49
+	Hs
		574644 RB11A_HUMAN (4-180): 7.77e-76: 228: 29.78		ARF4_HUMAN (46-240): 2.72e-63: 198: 20.51
+	Hs
		918879 RB11B_HUMAN (4-180): 2.7e-75: 226: 30.34		RAB1A_HUMAN (54-265): 1.14e-63: 200: 14.49
+	Mm
		919000 RAB1B_MOUSE (4-173): 2.73e-75: 226: 30.41		RAB1A_MOUSE (54-265): 1.14e-63: 200: 14.49
+	Hs
		914004 RB11A_HUMAN (4-180): 7.77e-76: 228: 29.78		ARF1_HUMAN (46-240): 2.73e-62: 195: 21.54