HitPredict

Interactor 1: UBE3C (Q15386)
Ubiquitin-protein ligase E3C (EC 2.3.2.26) (HECT-type ubiquitin transferase E3C) (Homologous to E6AP carboxyl terminus homologous protein 2) (HectH2) (RTA-associated ubiquitin ligase) (RAUL)
Gene: UBE3C

Interactor 2: ARRD2 (Q8TBH0)
Arrestin domain-containing protein 2
Gene: ARRDC2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.50	0.489

Property	Details
Experiments	38270169
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1083 Hs			1 407
+	Hs
		1072703 UBE3C_HUMAN (1-1083): 0: 1136: 100.00		ARRD3_HUMAN (1-406): 9.91e-136: 396: 52.90
+	Hs
		1072695 UBE3C_HUMAN (1-1083): 0: 1136: 100.00		ARRD4_HUMAN (4-395): 7.35e-115: 343: 46.58
+	Hs
		1072717 UBE3C_HUMAN (1-1083): 0: 1136: 100.00		TXNIP_HUMAN (1-393): 2.22e-109: 328: 37.59
+	Hs
		1252817 HECW2_HUMAN (262-1082): 0: 591: 19.91		ARRD2_HUMAN (1-407): 1.11e-144: 419: 100.00
+	Hs
		1285085 HECW2_HUMAN (262-1082): 0: 591: 19.91		ARRD3_HUMAN (1-406): 9.91e-136: 396: 52.90
+	Hs
		1252807 ITCH_HUMAN (594-1081): 5.52e-180: 550: 25.46		ARRD2_HUMAN (1-407): 1.11e-144: 419: 100.00
+	Hs
		808216 NEDD4_HUMAN (291-1081): 4.42e-178: 558: 20.10		ARRD3_HUMAN (1-406): 9.91e-136: 396: 52.90
+	Hs
		1285047 ITCH_HUMAN (594-1081): 5.52e-180: 550: 25.46		ARRD3_HUMAN (1-406): 9.91e-136: 396: 52.90
+	Hs
		1241904 ITCH_HUMAN (594-1081): 5.52e-180: 550: 25.46		ARRD4_HUMAN (4-395): 7.35e-115: 343: 46.58
+	Hs
		1294858 ITCH_HUMAN (594-1081): 5.52e-180: 550: 25.46		TXNIP_HUMAN (1-393): 2.22e-109: 328: 37.59
+	Dm
		115611 M9PFK2_DROME (292-1080): 6.37e-176: 543: 19.14		Q8SYU5_DROME (7-390): 9.05e-96: 296: 22.64
+	Hs
		808046 NEDD4_HUMAN (291-1081): 4.42e-178: 558: 20.10		ARRB1_HUMAN (12-373): 5.94e-85: 266: 14.09
+	Hs
		685841 NEDD4_HUMAN (291-1081): 4.42e-178: 558: 20.10		ARRB2_HUMAN (12-366): 3.18e-83: 261: 13.79
+	Hs
		1234613 HECW2_HUMAN (262-1082): 0: 591: 19.91		ARRD1_HUMAN (3-401): 1.6e-69: 227: 22.33
+	Hs
		827260 ITCH_HUMAN (594-1081): 5.52e-180: 550: 25.46		ARRB1_HUMAN (12-373): 5.94e-85: 266: 14.09
+	Hs
		686035 ITCH_HUMAN (594-1081): 5.52e-180: 550: 25.46		ARRB2_HUMAN (12-366): 3.18e-83: 261: 13.79
+	Mm
		1208049 ITCH_MOUSE (594-1081): 1.13e-179: 549: 25.46		ARRB2_MOUSE (12-366): 8.59e-81: 255: 13.51
+	Hs
		808187 NEDD4_HUMAN (291-1081): 4.42e-178: 558: 20.10		ARRD1_HUMAN (3-401): 1.6e-69: 227: 22.33
+	Hs
		1234600 ITCH_HUMAN (594-1081): 5.52e-180: 550: 25.46		ARRD1_HUMAN (3-401): 1.6e-69: 227: 22.33
+	Dm
		115612 M9PFK2_DROME (292-1080): 6.37e-176: 543: 19.14		Q9VGU4_DROME (18-302): 5.51e-62: 209: 20.14