HitPredict

Interactor 1: SF3B3 (Q15393)
Splicing factor 3B subunit 3 (Pre-mRNA-splicing factor SF3b 130 kDa subunit) (SF3b130) (STAF130) (Spliceosome-associated protein 130) (SAP 130)
Gene: SF3B3

Interactor 2: WDR59 (Q6PJI9)
GATOR2 complex protein WDR59 (WD repeat-containing protein 59)
Gene: WDR59

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.80	0.618

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CPSF_A~WD40, MMS1_N~WD40
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1217 Hs			1 974
+	Mm
		1112274 DDB1_MOUSE (2-1211): 0: 1062: 21.02		WDR59_MOUSE (1-974): 0: 790: 94.46
+	Hs
		1073094 SF3B3_HUMAN (1-1217): 0: 1474: 100.00		FBXW7_HUMAN (219-506): 1.23e-21: 102: 12.93
+	Hs
		1073127 SF3B3_HUMAN (1-1217): 0: 1474: 100.00		GRWD1_HUMAN (96-354): 6.12e-21: 99.1: 16.60
+	Hs
		1073168 SF3B3_HUMAN (1-1217): 0: 1474: 100.00		NLE1_HUMAN (3-88): 1.27e-17: 89.1: 7.78
+	Ce
		219829 O44985_CAEEL (1-1217): 0: 1304: 60.02		LIN53_CAEEL (104-371): 8.15e-17: 86.1: 19.07
+	Hs
		1082202 DDB1_HUMAN (2-1211): 0: 1062: 21.10		RBBP7_HUMAN (43-334): 3.53e-61: 216: 20.46
+	At
		186944 DDB1A_ARATH (2-1211): 0: 1039: 20.03		MSI1_ARATH (37-321): 7.06e-54: 195: 19.94
+	Hs
		903254 DDB1_HUMAN (2-1211): 0: 1062: 21.10		WDR5_HUMAN (180-476): 8.37e-46: 169: 14.38
+	Hs
		1082374 DDB1_HUMAN (2-1211): 0: 1062: 21.10		TBL1R_HUMAN (138-486): 7.41e-43: 166: 12.16
+	Hs
		1082263 DDB1_HUMAN (2-1211): 0: 1062: 21.10		WDR5B_HUMAN (180-476): 5.68e-43: 161: 13.40
+	Mm
		57142 DDB1_MOUSE (2-1211): 0: 1062: 21.02		BRWD3_MOUSE (3-209): 7.58e-32: 137: 10.37
+	Hs
		1082241 DDB1_HUMAN (2-1211): 0: 1062: 21.10		BRWD3_HUMAN (3-209): 2.06e-31: 135: 10.79
+	Hs
		1082298 DDB1_HUMAN (2-1211): 0: 1062: 21.10		PHIP_HUMAN (222-463): 1.44e-20: 100: 10.57
+	Hs
		1082355 DDB1_HUMAN (2-1211): 0: 1062: 21.10		GRWD1_HUMAN (96-354): 6.12e-21: 99.1: 16.60
+	At
		794497 DDB1A_ARATH (2-1211): 0: 1039: 20.03		COP1_ARATH (4-313): 3.44e-26: 117: 17.51
+	Hs
		997738 DDB1_HUMAN (2-1211): 0: 1062: 21.10		RBBP4_HUMAN (145-377): 1.33e-17: 88.4: 20.39
+	Hs
		1082327 DDB1_HUMAN (2-1211): 0: 1062: 21.10		SNR40_HUMAN (268-503): 1.87e-17: 87.2: 9.09
+	At
		221820 DDB1B_ARATH (1-1211): 0: 1032: 20.10		COP1_ARATH (4-313): 3.44e-26: 117: 17.51
+	At
		1340748 DDB1A_ARATH (2-1211): 0: 1039: 20.03		HTD1_ARATH (64-220): 5.23e-10: 65.1: 26.99
+	Hs
		197009 CPSF1_HUMAN (701-1216): 4.42e-121: 410: 15.99		PRP4_HUMAN (2-175): 7.43e-33: 136: 12.85