HitPredict

Interactor 1: SF3B3 (Q15393)
Splicing factor 3B subunit 3 (Pre-mRNA-splicing factor SF3b 130 kDa subunit) (SF3b130) (STAF130) (Spliceosome-associated protein 130) (SAP 130)
Gene: SF3B3

Interactor 2: SF3B5 (Q9BWJ5)
Splicing factor 3B subunit 5 (SF3b5) (Pre-mRNA-splicing factor SF3b 10 kDa subunit)
Gene: SF3B5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.912

The method score is based on:

Property	Details
Experiments	35271311, 27720643, 24981860, 35235311, 36652389
Identification Methods	affinity chromatography technology, x-ray crystallography, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	CPSF_A~SF3b10, MMS1_N~SF3b10
Common GO terms	GO:0000124 - SAGA complex GO:0000398 - mRNA splicing, via spliceosome GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005681 - spliceosomal complex and 8 others more... GO:0005684 - U2-type spliceosomal complex GO:0005686 - U2 snRNP GO:0005689 - U12-type spliceosomal complex GO:0006282 - regulation of DNA repair GO:0043484 - regulation of RNA splicing GO:0045893 - positive regulation of DNA-templated transcription GO:0071005 - U2-type precatalytic spliceosome GO:1903241 - U2-type prespliceosome assembly
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1	1217
Hs

1	86

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024