HitPredict

Interactor 1: TLR1 (Q15399)
Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281)
Gene: TLR1

Interactor 2: SIG10 (Q96LC7)
Sialic acid-binding Ig-like lectin 10 (Siglec-10) (Siglec-like protein 2)
Gene: SIGLEC10

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	25187624
Identification Methods	enzyme linked immunosorbent assay
Interaction Type	physical association

Property	Details
Interacting Pfam domains	I-set~LRR_8, Ig_3~LRR_8, LRR_8~V-set
Common GO terms	GO:0005886 - plasma membrane GO:0045087 - innate immune response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 786 Hs			1 697
+	Hs
		177599 TLR1_HUMAN (1-786): 1.5e-133: 417: 100.00		SIGL5_HUMAN (11-440): 8.2e-90: 292: 36.91
+	Hs
		177614 TLR6_HUMAN (5-781): 8.07e-124: 392: 68.86		SIGL5_HUMAN (11-440): 8.2e-90: 292: 36.91
+	Mm
		1144430 TLR6_MOUSE (5-780): 5.97e-124: 392: 59.92		CD33_MOUSE (1-235): 4.44e-89: 286: 47.66
+	Mm
		1113883 TLR6_MOUSE (5-780): 5.97e-124: 392: 59.92		Q3Y597_MOUSE (16-271): 5.9e-81: 261: 40.08
+	Hs
		177605 TLR10_HUMAN (1-785): 1e-111: 360: 46.25		SIGL5_HUMAN (11-440): 8.2e-90: 292: 36.91
+	Mm
		1265318 TLR2_MOUSE (1-776): 3.13e-95: 316: 27.27		SIGL5_MOUSE (1-697): 8.31e-104: 330: 28.65
+	Mm
		1144432 TLR2_MOUSE (1-776): 3.13e-95: 316: 27.27		CD33_MOUSE (1-235): 4.44e-89: 286: 47.66
+	Hs
		177592 TLR2_HUMAN (20-776): 9.9e-92: 306: 26.78		SIGL5_HUMAN (11-440): 8.2e-90: 292: 36.91
+	Mm
		1113884 TLR2_MOUSE (1-776): 3.13e-95: 316: 27.27		Q3Y597_MOUSE (16-271): 5.9e-81: 261: 40.08
+	Hs
		1073338 TLR1_HUMAN (1-786): 1.5e-133: 417: 100.00		SIGL9_HUMAN (278-697): 2.03e-23: 106: 20.00
+	Mm
		722907 TLR6_MOUSE (5-780): 5.97e-124: 392: 59.92		CD22_MOUSE (86-450): 4.58e-30: 128: 20.76
+	Hs
		590613 TLR10_HUMAN (1-785): 1e-111: 360: 46.25		CD22_HUMAN (102-510): 7.23e-32: 134: 21.01
+	Hs
		1315643 TLR10_HUMAN (1-785): 1e-111: 360: 46.25		SIGL9_HUMAN (278-697): 2.03e-23: 106: 20.00
+	Hs
		211422 TLR10_HUMAN (1-785): 1e-111: 360: 46.25		SIGL6_HUMAN (307-697): 3.19e-23: 105: 17.63
+	Mm
		722910 TLR2_MOUSE (1-776): 3.13e-95: 316: 27.27		CD22_MOUSE (86-450): 4.58e-30: 128: 20.76
+	Hs
		589580 TLR10_HUMAN (1-785): 1e-111: 360: 46.25		CD33_HUMAN (393-697): 1.93e-14: 77.3: 22.12
+	Dr
		1265014 Q9DE36_DANRE (7-637): 4.59e-53: 202: 13.42		Q90Z70_DANRE (7-666): 6.56e-62: 226: 12.73
+	Dr
		65452 Q9DE36_DANRE (7-637): 4.59e-53: 202: 13.42		A8DZ85_DANRE (1-664): 1.58e-60: 222: 13.44
+	Mm
		1162021 TLR2_MOUSE (1-776): 3.13e-95: 316: 27.27		Q6PJ50_MOUSE (307-679): 3.47e-23: 105: 20.40
+	Hs
		237523 TLR2_HUMAN (20-776): 9.9e-92: 306: 26.78		SIGL9_HUMAN (278-697): 2.03e-23: 106: 20.00