HitPredict

Interactor 1: TLR1 (Q15399)
Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281)
Gene: TLR1

Interactor 2: MYD88 (Q99836)
Myeloid differentiation primary response protein MyD88
Gene: MYD88

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.42	0.60	0.506

Property	Details
Experiments	19717524
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0032755 - positive regulation of interleukin-6 production GO:0032757 - positive regulation of interleukin-8 production GO:0032760 - positive regulation of tumor necrosis factor production and 1 others more... GO:0045087 - innate immune response
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 786 Hs			1 296
+	Hs
		1306793 TLR6_HUMAN (5-781): 8.07e-124: 392: 68.86		MYD88_HUMAN (14-296): 4.31e-123: 355: 100.00
+	Hs
		1306774 TLR10_HUMAN (1-785): 1e-111: 360: 46.25		MYD88_HUMAN (14-296): 4.31e-123: 355: 100.00
+	Mm
		607582 TLR2_MOUSE (1-776): 3.13e-95: 316: 27.27		MYD88_MOUSE (1-296): 6.79e-129: 370: 81.76
+	Hs
		1073332 TLR1_HUMAN (1-786): 1.5e-133: 417: 100.00		TLR10_HUMAN (145-295): 3.61e-51: 181: 19.88
+	Hs
		1073321 TLR1_HUMAN (1-786): 1.5e-133: 417: 100.00		TLR1_HUMAN (153-295): 1.02e-49: 177: 21.57
+	Hs
		1073336 TLR1_HUMAN (1-786): 1.5e-133: 417: 100.00		TLR6_HUMAN (153-295): 1.85e-48: 174: 20.26
+	Hs
		120154 TLR1_HUMAN (1-786): 1.5e-133: 417: 100.00		TLR4_HUMAN (153-293): 2.58e-46: 168: 26.00
+	Hs
		237496 TLR1_HUMAN (1-786): 1.5e-133: 417: 100.00		TLR2_HUMAN (161-293): 5.15e-45: 164: 23.78
+	Hs
		1315642 TLR6_HUMAN (5-781): 8.07e-124: 392: 68.86		TLR10_HUMAN (145-295): 3.61e-51: 181: 19.88
+	Hs
		886003 TLR1_HUMAN (1-786): 1.5e-133: 417: 100.00		TIRAP_HUMAN (106-287): 6.4e-46: 155: 21.31
+	Hs
		1377187 TLR6_HUMAN (5-781): 8.07e-124: 392: 68.86		TLR6_HUMAN (153-295): 1.85e-48: 174: 20.26
+	Hs
		120186 TLR6_HUMAN (5-781): 8.07e-124: 392: 68.86		TLR4_HUMAN (153-293): 2.58e-46: 168: 26.00
+	Hs
		237522 TLR6_HUMAN (5-781): 8.07e-124: 392: 68.86		TLR2_HUMAN (161-293): 5.15e-45: 164: 23.78
+	Hs
		1315638 TLR10_HUMAN (1-785): 1e-111: 360: 46.25		TLR10_HUMAN (145-295): 3.61e-51: 181: 19.88
+	Hs
		237517 TLR10_HUMAN (1-785): 1e-111: 360: 46.25		TLR2_HUMAN (161-293): 5.15e-45: 164: 23.78
+	Hs
		237446 TLR2_HUMAN (20-776): 9.9e-92: 306: 26.78		TLR2_HUMAN (161-293): 5.15e-45: 164: 23.78
+	Hs
		237484 TLR2_HUMAN (20-776): 9.9e-92: 306: 26.78		TIRAP_HUMAN (106-287): 6.4e-46: 155: 21.31