HitPredict

Interactor 1: NR6A1 (Q15406)
Nuclear receptor subfamily 6 group A member 1 (Germ cell nuclear factor) (GCNF) (hGCNF) (Retinoid receptor-related testis-specific receptor) (RTR) (hRTR)
Gene: NR6A1

Interactor 2: NCOA1 (Q15788)
Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1)
Gene: NCOA1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	23975195
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Hormone_recep~SRC-1
Common GO terms	GO:0000785 - chromatin GO:0005654 - nucleoplasm GO:0005667 - transcription regulator complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 480 Hs			1 1441
+	Hs
		130328 NR5A2_HUMAN (2-476): 1.77e-108: 334: 23.30		NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00
+	Hs
		490063 NR2F6_HUMAN (37-438): 5.48e-106: 322: 26.90		NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00
+	Hs
		369684 ESR1_HUMAN (12-475): 3.51e-90: 288: 19.71		NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00
+	Hs
		1025256 NR1H3_HUMAN (2-469): 2.02e-89: 281: 21.80		NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00
+	Hs
		1030588 STF1_HUMAN (48-476): 1.79e-87: 277: 21.30		NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00
+	Mm
		703484 STF1_MOUSE (48-476): 6.84e-94: 293: 22.34		NCOA1_MOUSE (1-1441): 3.4e-149: 493: 92.19
+	Hs
		874384 NR1H2_HUMAN (7-469): 2.37e-87: 276: 21.56		NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00
+	Mm
		936666 NR1H3_MOUSE (2-469): 1.66e-89: 282: 21.10		NCOA1_MOUSE (1-1441): 3.4e-149: 493: 92.19
+	Hs
		370292 ESR1_HUMAN (12-475): 3.51e-90: 288: 19.71		EPAS1_HUMAN (15-890): 5.41e-104: 354: 13.27
+	Hs
		369703 ESR1_HUMAN (12-475): 3.51e-90: 288: 19.71		HIF1A_HUMAN (8-798): 3.33e-103: 351: 13.33
+	Hs
		130340 NR5A2_HUMAN (2-476): 1.77e-108: 334: 23.30		NCOA3_HUMAN (1-1343): 5.25e-75: 277: 24.33
+	Mm
		222608 NR1I2_MOUSE (47-453): 1.82e-97: 302: 23.40		Q05BA5_MOUSE (1-1411): 1.11e-76: 282: 23.77
+	Hs
		369099 ESR1_HUMAN (12-475): 3.51e-90: 288: 19.71		AHR_HUMAN (2-833): 8.86e-80: 284: 13.86
+	Hs
		370839 ESR1_HUMAN (12-475): 3.51e-90: 288: 19.71		NCOA3_HUMAN (1-1343): 5.25e-75: 277: 24.33
+	Mm
		60470 NR1I2_MOUSE (47-453): 1.82e-97: 302: 23.40		A5D6Q2_MOUSE (48-1411): 3.96e-70: 261: 22.54
+	Hs
		1025276 NR1H3_HUMAN (2-469): 2.02e-89: 281: 21.80		NCOA3_HUMAN (1-1343): 5.25e-75: 277: 24.33
+	Hs
		369025 ESR1_HUMAN (12-475): 3.51e-90: 288: 19.71		ARNT_HUMAN (1-642): 5.73e-69: 250: 16.45
+	Hs
		130327 NR5A2_HUMAN (2-476): 1.77e-108: 334: 23.30		NCOA2_HUMAN (496-1439): 2.6e-11: 70.7: 9.43
+	Hs
		369673 ESR1_HUMAN (12-475): 3.51e-90: 288: 19.71		NCOA2_HUMAN (496-1439): 2.6e-11: 70.7: 9.43
+	Hs
		69414 ESR1_HUMAN (12-475): 3.51e-90: 288: 19.71		AHRR_HUMAN (29-186): 6.1e-09: 62.8: 31.10