HitPredict

Interactor 1: KS6A1 (Q15418)
Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1)
Gene: RPS6KA1

Interactor 2: NHRF2 (Q15599)
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1)
Gene: NHERF2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.27	0.50	0.373

Property	Details
Experiments	30726710
Identification Methods	unspecified method
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 735 Hs			1 337
+	Hs
		850657 KS6A3_HUMAN (1-735): 0: 791: 79.14		NHRF2_HUMAN (1-337): 6.02e-79: 246: 100.00
+	Hs
		153900 KS6A3_HUMAN (1-735): 0: 791: 79.14		NHRF1_HUMAN (2-337): 3.61e-70: 224: 48.87
+	Hs
		1073438 KS6A1_HUMAN (1-735): 0: 836: 100.00		PZRN4_HUMAN (5-336): 1.72e-40: 153: 15.92
+	Hs
		1073491 KS6A1_HUMAN (1-735): 0: 836: 100.00		WHRN_HUMAN (3-250): 2.49e-40: 152: 22.22
+	Hs
		1073444 KS6A1_HUMAN (1-735): 0: 836: 100.00		MAGI2_HUMAN (3-192): 5.72e-19: 90: 17.19
+	Hs
		1073434 KS6A1_HUMAN (1-735): 0: 836: 100.00		MAGI3_HUMAN (14-296): 6.63e-18: 86.9: 18.15
+	Hs
		1073470 KS6A1_HUMAN (1-735): 0: 836: 100.00		MAGI1_HUMAN (2-204): 1.44e-16: 83.1: 21.95
+	Hs
		942348 KS6A1_HUMAN (1-735): 0: 836: 100.00		DLG4_HUMAN (106-233): 1.85e-14: 76.2: 21.48
+	Hs
		1049960 KS6A1_HUMAN (1-735): 0: 836: 100.00		SCRIB_HUMAN (4-185): 3.63e-13: 72.7: 18.37
+	Hs
		1073433 KS6A1_HUMAN (1-735): 0: 836: 100.00		NHRF3_HUMAN (148-263): 7.43e-11: 65: 28.45
+	Hs
		1073467 KS6A1_HUMAN (1-735): 0: 836: 100.00		SNX27_HUMAN (149-228): 1.89e-09: 60.8: 38.71
+	Hs
		850651 KS6A3_HUMAN (1-735): 0: 791: 79.14		SCRIB_HUMAN (4-185): 3.63e-13: 72.7: 18.37
+	Hs
		850702 KS6A3_HUMAN (1-735): 0: 791: 79.14		SNX27_HUMAN (149-228): 1.89e-09: 60.8: 38.71
+	Hs
		153882 AKT1_HUMAN (411-724): 3.69e-122: 375: 25.92		NHRF1_HUMAN (2-337): 3.61e-70: 224: 48.87
+	Hs
		681891 AKT1_HUMAN (411-724): 3.69e-122: 375: 25.92		NHRF3_HUMAN (148-263): 7.43e-11: 65: 28.45
+	Hs
		682200 AKT2_HUMAN (326-719): 8.47e-124: 379: 22.11		SNX27_HUMAN (149-228): 1.89e-09: 60.8: 38.71
+	Mm
		933108 KAPCB_MOUSE (416-712): 7.52e-113: 346: 29.90		DLG4_MOUSE (106-233): 1.85e-14: 76.2: 21.48
+	Hs
		647882 MARK3_HUMAN (408-695): 1.9e-108: 348: 28.48		PTN13_HUMAN (89-239): 2.59e-11: 66.9: 21.05
+	Mm
		1143553 KS6A2_MOUSE (2-331): 2.44e-102: 332: 23.68		DLG4_MOUSE (106-233): 1.85e-14: 76.2: 21.48
+	Hs
		1021498 KS6A2_HUMAN (2-321): 2.57e-98: 321: 23.80		DLG1_HUMAN (87-235): 1.55e-13: 73.5: 17.31