HitPredict

Interactor 1: KS6A1 (Q15418)
Ribosomal protein S6 kinase alpha-1 (S6K-alpha-1) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 1) (p90-RSK 1) (p90RSK1) (p90S6K) (MAP kinase-activated protein kinase 1a) (MAPK-activated protein kinase 1a) (MAPKAP kinase 1a) (MAPKAPK-1a) (Ribosomal S6 kinase 1) (RSK-1)
Gene: RPS6KA1

Interactor 2: PKHA4 (Q9H4M7)
Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1)
Gene: PLEKHA4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31091453
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Pkinase
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 735 Hs			1 779
+	Hs
		850712 KS6A3_HUMAN (1-735): 0: 791: 79.14		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		270445 KS6A5_HUMAN (46-730): 0: 706: 41.42		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		272901 KS6A4_HUMAN (49-734): 0: 649: 41.33		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		682210 AKT2_HUMAN (326-719): 8.47e-124: 379: 22.11		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		682023 AKT1_HUMAN (411-724): 3.69e-122: 375: 25.92		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		568795 KAPCA_HUMAN (414-712): 3.66e-114: 350: 29.71		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		610780 KAPCB_HUMAN (406-704): 9.71e-114: 349: 30.03		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		647959 MARK3_HUMAN (408-695): 1.9e-108: 348: 28.48		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Dm
		1358808 JIL1_DROME (8-700): 0: 570: 32.40		Q9VZQ3_DROME (17-338): 1.01e-39: 161: 13.02
+	Hs
		681831 AKT1_HUMAN (411-724): 3.69e-122: 375: 25.92		GAB1_HUMAN (52-611): 6.48e-53: 197: 13.92
+	Rn
		1144020 AKT3_RAT (358-719): 2.65e-121: 373: 21.60		CAPS1_RAT (11-428): 1.59e-46: 181: 10.23
+	Hs
		568704 KAPCA_HUMAN (414-712): 3.66e-114: 350: 29.71		PKHA7_HUMAN (2-440): 4.98e-50: 192: 28.02
+	Mm
		933111 KAPCB_MOUSE (416-712): 7.52e-113: 346: 29.90		CNKR2_MOUSE (1-468): 7.51e-48: 185: 14.40
+	Hs
		568798 KAPCA_HUMAN (414-712): 3.66e-114: 350: 29.71		PKHA5_HUMAN (2-653): 1.62e-36: 150: 17.61
+	Hs
		1071703 KS6A2_HUMAN (2-321): 2.57e-98: 321: 23.80		PKHA5_HUMAN (2-653): 1.62e-36: 150: 17.61