HitPredict

Interactor 1: SF3A1 (Q15459)
Splicing factor 3A subunit 1 (SF3a120) (Spliceosome-associated protein 114) (SAP 114)
Gene: SF3A1

Interactor 2: THOC6 (Q86W42)
THO complex subunit 6 homolog (Functional spliceosome-associated protein 35) (fSAP35) (WD repeat-containing protein 58)
Gene: THOC6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006397 - mRNA processing GO:0016607 - nuclear speck
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 793 Hs			1 341
+	Hs
		197027 SF3A1_HUMAN (1-793): 1.4e-107: 349: 100.00		PRP4_HUMAN (2-244): 2.6e-52: 182: 12.65
+	Hs
		236225 SF3A1_HUMAN (1-793): 1.4e-107: 349: 100.00		PRP17_HUMAN (1-284): 9.1e-50: 176: 8.67
+	Hs
		1074201 SF3A1_HUMAN (1-793): 1.4e-107: 349: 100.00		SNR40_HUMAN (1-152): 5.89e-29: 116: 14.65
+	Hs
		1264784 TITIN_HUMAN (293-702): 3.81e-38: 156: 16.70		SNR40_HUMAN (1-152): 5.89e-29: 116: 14.65
+	Hs
		1146674 TITIN_HUMAN (293-702): 3.81e-38: 156: 16.70		A16L1_HUMAN (65-330): 1.22e-16: 82.9: 15.39
+	Hs
		152678 KMT2D_HUMAN (538-699): 7.37e-26: 117: 22.35		FBXW7_HUMAN (1-149): 4.03e-22: 99.3: 7.38
+	Hs
		152622 KMT2D_HUMAN (538-699): 7.37e-26: 117: 22.35		WDR5_HUMAN (1-103): 1.25e-14: 75.4: 13.76
+	Hs
		152663 KMT2D_HUMAN (538-699): 7.37e-26: 117: 22.35		WDR5B_HUMAN (1-102): 2.6e-14: 74.6: 14.82
+	Hs
		903105 RS27A_HUMAN (722-790): 7.14e-21: 92: 30.44		WDR5_HUMAN (1-103): 1.25e-14: 75.4: 13.76
+	Mm
		903669 KMT2C_MOUSE (183-760): 1.55e-11: 70.7: 9.45		WDR5_MOUSE (1-103): 1.25e-14: 75.4: 13.76