Interactor 1: SHH (Q15465)
Sonic hedgehog protein (SHH) (EC 3.1.-.-) (HHG-1) (Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains) (ShhNC) [Cleaved into: Sonic hedgehog protein N-product (ShhN) (Shh N-terminal processed signaling domains) (ShhNp)]
Gene: SHH
Interactor 2: HHIP (Q96QV1)
Hedgehog-interacting protein (HHIP) (HIP)
Gene: HHIP
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.57 | 1.00 | 0.761 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 19561609 |
| Identification Methods | enzyme linked immunosorbent assay, nuclear magnetic resonance, solid phase assay, bio-layer interferometry |
| Interaction Type | direct interaction, physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | GSDH~HH_signal |
| Common GO terms | GO:0005576 - extracellular region GO:0005886 - plasma membrane GO:0007405 - neuroblast proliferation GO:0008270 - zinc ion binding GO:0009953 - dorsal/ventral pattern formation and 2 others more... |
| Homologous interactions | 4 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 15 Jul 2024
