HitPredict

Interactor 1: SIX1 (Q15475)
Homeobox protein SIX1 (Sine oculis homeobox homolog 1)
Gene: SIX1

Interactor 2: EYA1 (Q99502)
Eyes absent homolog 1 (EC 3.1.3.16) (EC 3.1.3.48)
Gene: EYA1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.90 1.00 0.952

The method score is based on:

Property Details
Experiments 32296183, 11734542, 26186194, 28514442, 33961781, unassigned1304
Identification Methods two hybrid, affinity chromatography technology, pull down, anti tag coimmunoprecipitation, two hybrid array, validated two hybrid, two hybrid prey pooling approach
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Hydrolase~SIX1_SD
Common GO terms GO:0001658 - branching involved in ureteric bud morphogenesis
GO:0003151 - outflow tract morphogenesis
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
and 11 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 284
Hs

1 592
+ Mm
+ Hs
+ Mm
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Mm
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Mm
+ Mm
+ Dm

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024