HitPredict

Interactor 1: MED22 (Q15528)
Mediator of RNA polymerase II transcription subunit 22 (Mediator complex subunit 22) (Surfeit locus protein 5) (Surf-5)
Gene: MED22

Interactor 2: MED11 (Q9P086)
Mediator of RNA polymerase II transcription subunit 11 (Mediator complex subunit 11)
Gene: MED11

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.911

The method score is based on:

Property	Details
Experiments	12584197, 24981860, 33961781, 35271311
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	Med11~Med22
Common GO terms	GO:0003712 - transcription coregulator activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016592 - mediator complex GO:0032968 - positive regulation of transcription elongation by RNA polymerase II and 3 others more... GO:0051123 - RNA polymerase II preinitiation complex assembly GO:0060261 - positive regulation of transcription initiation by RNA polymerase II GO:0070847 - core mediator complex
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1	200
Hs

1	117

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024