HitPredict

Interactor 1: TERF2 (Q15554)
Telomeric repeat-binding factor 2 (TTAGGG repeat-binding factor 2) (Telomeric DNA-binding protein)
Gene: TERF2

Interactor 2: POTE1 (Q9NUX5)
Protection of telomeres protein 1 (hPot1) (POT1-like telomere end-binding protein)
Gene: POT1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	0.60	0.755

The method score is based on:

Property	Details
Experiments	20811636, 15383534, 26496610, 28514442, 33961781, 35271311, 19287395, 19651898
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000781 - chromosome, telomeric region GO:0000783 - nuclear telomere cap complex GO:0005654 - nucleoplasm GO:0016233 - telomere capping GO:0032206 - positive regulation of telomere maintenance and 6 others more... GO:0032210 - regulation of telomere maintenance via telomerase GO:0032211 - negative regulation of telomere maintenance via telomerase GO:0042162 - telomeric DNA binding GO:0061820 - telomeric D-loop disassembly GO:0070187 - shelterin complex GO:0098505 - G-rich strand telomeric DNA binding
Homologous interactions	1

Homologous interactions

Color coding for hit scores

	1	542
Hs

1	634

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024