HitPredict

Interactor 1: TEAD4 (Q15561)
Transcriptional enhancer factor TEF-3 (TEA domain family member 4) (TEAD-4) (Transcription factor 13-like 1) (Transcription factor RTEF-1)
Gene: TEAD4

Interactor 2: WWTR1 (Q9GZV5)
WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif)
Gene: WWTR1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	0.60	0.758

Property	Details
Experiments	25670202, 26116754, 30472188, 32296183, 26186194, 16189514, 28514442, 33961781, 35931679, 20972459, 31515488, unassigned1304
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, two hybrid array, validated two hybrid, two hybrid prey pooling approach, two hybrid pooling approach
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005667 - transcription regulator complex GO:0005737 - cytoplasm GO:0035329 - hippo signaling
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 434 Hs			1 400
+	Mm
		1143754 TEAD4_MOUSE (8-434): 0: 770: 93.68		WWTR1_MOUSE (1-400): 7.96e-120: 355: 91.00
+	Hs
		658558 TEAD1_HUMAN (8-434): 0: 733: 74.54		WWTR1_HUMAN (1-400): 5.62e-126: 370: 100.00
+	Mm
		671381 TEAD1_MOUSE (8-434): 0: 734: 74.77		WWTR1_MOUSE (1-400): 7.96e-120: 355: 91.00
+	Hs
		808635 TEAD4_HUMAN (1-434): 0: 784: 100.00		YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13
+	Mm
		809073 TEAD4_MOUSE (8-434): 0: 770: 93.68		YAP1_MOUSE (15-400): 5.62e-100: 307: 41.30
+	Mm
		1113240 Q3USK5_MOUSE (24-434): 0: 716: 72.56		WWTR1_MOUSE (1-400): 7.96e-120: 355: 91.00
+	Hs
		1304848 TEAD3_HUMAN (21-434): 0: 691: 70.82		WWTR1_HUMAN (1-400): 5.62e-126: 370: 100.00
+	Mm
		936316 TEAD3_MOUSE (8-434): 0: 691: 68.55		WWTR1_MOUSE (1-400): 7.96e-120: 355: 91.00
+	Mm
		671378 TEAD1_MOUSE (8-434): 0: 734: 74.77		YAP1_MOUSE (15-400): 5.62e-100: 307: 41.30
+	Hs
		658469 TEAD1_HUMAN (8-434): 0: 733: 74.54		YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13
+	Hs
		1075251 TEAD2_HUMAN (40-434): 0: 648: 65.93		WWTR1_HUMAN (1-400): 5.62e-126: 370: 100.00
+	Mm
		809065 TEAD3_MOUSE (8-434): 0: 691: 68.55		YAP1_MOUSE (15-400): 5.62e-100: 307: 41.30
+	Hs
		808875 TEAD3_HUMAN (21-434): 0: 691: 70.82		YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13
+	Mm
		817006 TEAD2_MOUSE (38-434): 0: 628: 65.20		WWTR1_MOUSE (1-400): 7.96e-120: 355: 91.00
+	Hs
		808636 TEAD2_HUMAN (40-434): 0: 648: 65.93		YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13
+	Mm
		809063 TEAD2_MOUSE (38-434): 0: 628: 65.20		YAP1_MOUSE (15-400): 5.62e-100: 307: 41.30
+	Dm
		671392 SCAL_DROME (6-434): 0: 618: 58.58		YAP1_DROME (17-223): 5.05e-46: 164: 22.80
+	Hs
		808133 TEAD2_HUMAN (40-434): 0: 648: 65.93		NEDD4_HUMAN (109-352): 7.33e-23: 103: 11.00
+	Sc
		576198 TEC1_YEAST (43-259): 1.45e-31: 127: 25.39		RSP5_YEAST (60-356): 4.36e-33: 133: 13.24