HitPredict

Interactor 1: NHRF2 (Q15599)
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1)
Gene: NHERF2

Interactor 2: PHLP2 (Q6ZVD8)
PH domain leucine-rich repeat-containing protein phosphatase 2 (EC 3.1.3.16) (PH domain leucine-rich repeat-containing protein phosphatase-like) (PHLPP-like)
Gene: PHLPP2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.50	0.613

Property	Details
Experiments	33961781, 27880917, 19615732
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 337 Hs			1 1323
+	Hs
		153932 NHRF1_HUMAN (2-337): 3.61e-70: 224: 48.87		PHLP2_HUMAN (1-1323): 0: 993: 100.00
+	Hs
		232891 NHRF2_HUMAN (1-337): 6.02e-79: 246: 100.00		PHLP1_HUMAN (36-1300): 0: 845: 53.04
+	Hs
		153848 NHRF1_HUMAN (2-337): 3.61e-70: 224: 48.87		PHLP1_HUMAN (36-1300): 0: 845: 53.04
+	Hs
		1172965 SNX27_HUMAN (149-228): 1.89e-09: 60.8: 38.71		PHLP2_HUMAN (1-1323): 0: 993: 100.00
+	Hs
		232859 DLG1_HUMAN (87-235): 1.55e-13: 73.5: 17.31		PHLP1_HUMAN (36-1300): 0: 845: 53.04
+	Hs
		232877 SCRIB_HUMAN (4-185): 3.63e-13: 72.7: 18.37		PHLP1_HUMAN (36-1300): 0: 845: 53.04
+	Hs
		232963 SNX27_HUMAN (149-228): 1.89e-09: 60.8: 38.71		PHLP1_HUMAN (36-1300): 0: 845: 53.04
+	Dm
		677695 DLG1_DROME (12-325): 4.79e-25: 108: 16.57		SCRIB_DROME (513-779): 9.01e-12: 72.4: 25.51
+	Hs
		1050066 SCRIB_HUMAN (4-185): 3.63e-13: 72.7: 18.37		LRC40_HUMAN (249-701): 1.53e-22: 105: 27.03
+	Hs
		942375 DLG4_HUMAN (106-233): 1.85e-14: 76.2: 21.48		LRRC1_HUMAN (513-772): 7.92e-14: 77.8: 29.83
+	Hs
		942369 DLG4_HUMAN (106-233): 1.85e-14: 76.2: 21.48		LRRC7_HUMAN (448-746): 2.05e-13: 77.4: 28.89
+	Mm
		1143366 DLG4_MOUSE (106-233): 1.85e-14: 76.2: 21.48		LRRC7_MOUSE (448-746): 2.69e-13: 77: 28.89
+	Rn
		677773 DLG4_RAT (106-233): 1.75e-14: 76.2: 21.48		LRRC7_RAT (448-746): 2.69e-13: 77: 28.89
+	Hs
		1021557 DLG1_HUMAN (87-235): 1.55e-13: 73.5: 17.31		LRRC1_HUMAN (513-772): 7.92e-14: 77.8: 29.83
+	Hs
		1050046 SCRIB_HUMAN (4-185): 3.63e-13: 72.7: 18.37		LRRC1_HUMAN (513-772): 7.92e-14: 77.8: 29.83
+	Mm
		1143369 DLG4_MOUSE (106-233): 1.85e-14: 76.2: 21.48		ERBIN_MOUSE (523-772): 4.62e-11: 69.7: 27.17
+	Hs
		1296886 SNX27_HUMAN (149-228): 1.89e-09: 60.8: 38.71		LRRC1_HUMAN (513-772): 7.92e-14: 77.8: 29.83