HitPredict

Interactor 1: NHRF2 (Q15599)
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1)
Gene: NHERF2

Interactor 2: OTUL (Q96BN8)
Ubiquitin thioesterase otulin (EC 3.4.19.12) (Deubiquitinating enzyme otulin) (OTU domain-containing deubiquitinase with linear linkage specificity) (Ubiquitin thioesterase Gumby)
Gene: OTULIN

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.80	0.705

Property	Details
Experiments	33961781, 37589075
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PDZ~Peptidase_C101
Common GO terms	-
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 337 Hs			1 352
+	Hs
		153940 NHRF1_HUMAN (2-337): 3.61e-70: 224: 48.87		OTUL_HUMAN (1-352): 0: 630: 100.00
+	Hs
		67918 PDZ1P_HUMAN (4-131): 1.03e-19: 91.2: 33.59		OTUL_HUMAN (1-352): 0: 630: 100.00
+	Hs
		1050024 SCRIB_HUMAN (4-185): 3.63e-13: 72.7: 18.37		OTUL_HUMAN (1-352): 0: 630: 100.00
+	Hs
		1132913 NHRF3_HUMAN (148-263): 7.43e-11: 65: 28.45		OTUL_HUMAN (1-352): 0: 630: 100.00
+	Hs
		1285690 SNX27_HUMAN (149-228): 1.89e-09: 60.8: 38.71		OTUL_HUMAN (1-352): 0: 630: 100.00