HitPredict

Interactor 1: NHRF2 (Q15599)
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1)
Gene: NHERF2

Interactor 2: WWTR1 (Q9GZV5)
WW domain-containing transcription regulator protein 1 (Transcriptional coactivator with PDZ-binding motif)
Gene: WWTR1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.621

Property	Details
Experiments	11118213, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 337 Hs			1 400
+	Hs
		808637 NHRF2_HUMAN (1-337): 6.02e-79: 246: 100.00		YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13
+	Hs
		153894 NHRF1_HUMAN (2-337): 3.61e-70: 224: 48.87		YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13
+	Hs
		125481 NHRF2_HUMAN (1-337): 6.02e-79: 246: 100.00		WWP2_HUMAN (3-220): 6.4e-59: 207: 19.46
+	Hs
		280067 MPDZ_HUMAN (7-184): 3.68e-14: 75.7: 21.16		WWTR1_HUMAN (1-400): 5.62e-126: 370: 100.00
+	Hs
		1021560 DLG1_HUMAN (87-235): 1.55e-13: 73.5: 17.31		WWTR1_HUMAN (1-400): 5.62e-126: 370: 100.00
+	Hs
		280032 MPDZ_HUMAN (7-184): 3.68e-14: 75.7: 21.16		YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13
+	Hs
		808565 DLG1_HUMAN (87-235): 1.55e-13: 73.5: 17.31		YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13
+	Hs
		808786 INADL_HUMAN (3-129): 2.49e-13: 73: 21.81		YAP1_HUMAN (14-400): 3.72e-97: 300: 41.13
+	Dm
		1001633 Q0KHR3_DROME (28-333): 3.13e-36: 141: 22.47		Q9W2L2_DROME (11-209): 8.85e-41: 156: 17.59
+	Hs
		125592 INADL_HUMAN (3-129): 2.49e-13: 73: 21.81		WWP2_HUMAN (3-220): 6.4e-59: 207: 19.46
+	Hs
		280050 MPDZ_HUMAN (7-184): 3.68e-14: 75.7: 21.16		KIBRA_HUMAN (123-265): 3.08e-45: 169: 18.88
+	Hs
		1199788 MAGI2_HUMAN (3-192): 5.72e-19: 90: 17.19		MAGI1_HUMAN (10-212): 9.04e-40: 153: 15.74
+	Hs
		1021531 DLG1_HUMAN (87-235): 1.55e-13: 73.5: 17.31		KIBRA_HUMAN (123-265): 3.08e-45: 169: 18.88
+	Hs
		1220068 INADL_HUMAN (3-129): 2.49e-13: 73: 21.81		KIBRA_HUMAN (123-265): 3.08e-45: 169: 18.88
+	Mm
		1143518 DLG4_MOUSE (106-233): 1.85e-14: 76.2: 21.48		MAGI3_MOUSE (3-246): 8.06e-44: 165: 18.88
+	Hs
		1300658 MAGI1_HUMAN (2-204): 1.44e-16: 83.1: 21.95		MAGI1_HUMAN (10-212): 9.04e-40: 153: 15.74
+	Mm
		1143429 DLG4_MOUSE (106-233): 1.85e-14: 76.2: 21.48		NED4L_MOUSE (129-395): 4.63e-24: 106: 11.96
+	Mm
		93273 DLG4_MOUSE (106-233): 1.85e-14: 76.2: 21.48		E9PXB7_MOUSE (129-395): 7.76e-23: 102: 12.68
+	Hs
		280084 MPDZ_HUMAN (7-184): 3.68e-14: 75.7: 21.16		WWOX_HUMAN (111-236): 1.79e-18: 88.4: 21.09
+	Hs
		1299602 MAGI1_HUMAN (2-204): 1.44e-16: 83.1: 21.95		NED4L_HUMAN (164-352): 3.03e-13: 73.5: 13.20