HitPredict

Interactor 1: NHRF2 (Q15599)
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1)
Gene: NHERF2

Interactor 2: LPAR2 (Q9HBW0)
Lysophosphatidic acid receptor 2 (LPA receptor 2) (LPA-2) (Lysophosphatidic acid receptor Edg-4)
Gene: LPAR2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	15143197, 19293149, 16203867
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 337 Hs			1 348
+	Hs
		429050 NHRF2_HUMAN (1-337): 6.02e-79: 246: 100.00		ADRB2_HUMAN (1-331): 2.32e-71: 229: 19.95
+	Hs
		664359 NHRF2_HUMAN (1-337): 6.02e-79: 246: 100.00		AA2BR_HUMAN (26-319): 9.19e-67: 215: 24.61
+	Hs
		153858 NHRF1_HUMAN (2-337): 3.61e-70: 224: 48.87		ADRB2_HUMAN (1-331): 2.32e-71: 229: 19.95
+	Hs
		153888 NHRF1_HUMAN (2-337): 3.61e-70: 224: 48.87		OPRK_HUMAN (7-325): 3.96e-63: 207: 15.66
+	Mm
		578603 MAGI3_MOUSE (14-296): 5.46e-17: 84.2: 18.47		ADRB2_MOUSE (1-334): 9.43e-73: 233: 20.33
+	Hs
		429068 MAGI3_HUMAN (14-296): 6.63e-18: 86.9: 18.15		ADRB2_HUMAN (1-331): 2.32e-71: 229: 19.95
+	Rn
		495779 DLG4_RAT (106-233): 1.75e-14: 76.2: 21.48		ADRB2_RAT (1-336): 5.6e-72: 231: 19.95
+	Mm
		676818 DLG4_MOUSE (106-233): 1.85e-14: 76.2: 21.48		SSR2_MOUSE (13-339): 5.84e-72: 229: 15.98
+	Rn
		677498 DLG4_RAT (106-233): 1.75e-14: 76.2: 21.48		SSR4_RAT (30-312): 5.97e-71: 227: 24.06
+	Mm
		676813 DLG2_MOUSE (79-232): 1.54e-14: 76.5: 18.63		SSR1_MOUSE (15-311): 1.2e-69: 224: 20.26
+	Mm
		676812 DLG4_MOUSE (106-233): 1.85e-14: 76.2: 21.48		SSR1_MOUSE (15-311): 1.2e-69: 224: 20.26
+	Mm
		830268 DLG2_MOUSE (79-232): 1.54e-14: 76.5: 18.63		SSR4_MOUSE (1-312): 2.3e-69: 223: 21.25
+	Hs
		441654 MAGI2_HUMAN (3-192): 5.72e-19: 90: 17.19		ADRB1_HUMAN (4-329): 6.23e-63: 209: 18.54
+	Hs
		441653 MAGI3_HUMAN (14-296): 6.63e-18: 86.9: 18.15		ADRB1_HUMAN (4-329): 6.23e-63: 209: 18.54
+	Hs
		697555 MAGI3_HUMAN (14-296): 6.63e-18: 86.9: 18.15		SSR3_HUMAN (15-327): 2.67e-63: 208: 19.63
+	Hs
		441656 MAGI1_HUMAN (2-204): 1.44e-16: 83.1: 21.95		ADRB1_HUMAN (4-329): 6.23e-63: 209: 18.54
+	Hs
		697558 MAGI1_HUMAN (2-204): 1.44e-16: 83.1: 21.95		SSR3_HUMAN (15-327): 2.67e-63: 208: 19.63
+	Hs
		441650 DLG4_HUMAN (106-233): 1.85e-14: 76.2: 21.48		ADRB1_HUMAN (4-329): 6.23e-63: 209: 18.54
+	Hs
		656994 DLG4_HUMAN (106-233): 1.85e-14: 76.2: 21.48		5HT2A_HUMAN (17-345): 5.14e-63: 209: 16.94
+	Hs
		600726 DLG4_HUMAN (106-233): 1.85e-14: 76.2: 21.48		DRD1_HUMAN (23-330): 3.03e-62: 206: 18.36