HitPredict

Interactor 1: NHRF2 (Q15599)
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1)
Gene: NHERF2

Interactor 2: KCTD5 (Q9NXV2)
BTB/POZ domain-containing protein KCTD5
Gene: KCTD5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	27173435, 33961781
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 337 Hs			1 234
+	Hs
		153954 NHRF1_HUMAN (2-337): 3.61e-70: 224: 48.87		KCTD5_HUMAN (1-234): 6.84e-87: 258: 100.00
+	Hs
		1057222 NHRF2_HUMAN (1-337): 6.02e-79: 246: 100.00		KCTD2_HUMAN (11-234): 1.24e-75: 231: 71.56
+	Hs
		153919 NHRF1_HUMAN (2-337): 3.61e-70: 224: 48.87		KCTD2_HUMAN (11-234): 1.24e-75: 231: 71.56
+	Hs
		1075429 NHRF2_HUMAN (1-337): 6.02e-79: 246: 100.00		KCD17_HUMAN (44-225): 3e-61: 196: 78.57
+	Hs
		1075459 NHRF2_HUMAN (1-337): 6.02e-79: 246: 100.00		BACD3_HUMAN (20-224): 6.9e-57: 184: 22.82
+	Hs
		1075479 NHRF2_HUMAN (1-337): 6.02e-79: 246: 100.00		KCTD3_HUMAN (20-138): 1.12e-40: 149: 38.66
+	Hs
		1075432 NHRF2_HUMAN (1-337): 6.02e-79: 246: 100.00		SHKB1_HUMAN (40-150): 1.22e-35: 135: 40.54
+	Hs
		153961 NHRF1_HUMAN (2-337): 3.61e-70: 224: 48.87		KCTD3_HUMAN (20-138): 1.12e-40: 149: 38.66
+	Hs
		153935 NHRF1_HUMAN (2-337): 3.61e-70: 224: 48.87		SHKB1_HUMAN (40-150): 1.22e-35: 135: 40.54
+	Hs
		67923 PDZ1P_HUMAN (4-131): 1.03e-19: 91.2: 33.59		KCTD5_HUMAN (1-234): 6.84e-87: 258: 100.00
+	Hs
		67909 PDZ1P_HUMAN (4-131): 1.03e-19: 91.2: 33.59		KCTD2_HUMAN (11-234): 1.24e-75: 231: 71.56
+	Hs
		67915 PDZ1P_HUMAN (4-131): 1.03e-19: 91.2: 33.59		KCD17_HUMAN (44-225): 3e-61: 196: 78.57
+	Hs
		942389 DLG4_HUMAN (106-233): 1.85e-14: 76.2: 21.48		KCND2_HUMAN (16-180): 1.69e-48: 170: 23.46
+	Hs
		67925 PDZ1P_HUMAN (4-131): 1.03e-19: 91.2: 33.59		KCTD3_HUMAN (20-138): 1.12e-40: 149: 38.66
+	Hs
		1300703 MAGI1_HUMAN (2-204): 1.44e-16: 83.1: 21.95		KCTD3_HUMAN (20-138): 1.12e-40: 149: 38.66
+	Hs
		67916 PDZ1P_HUMAN (4-131): 1.03e-19: 91.2: 33.59		SHKB1_HUMAN (40-150): 1.22e-35: 135: 40.54
+	Rn
		626888 DLG1_RAT (87-232): 1.5e-13: 73.5: 18.30		KCNC1_RAT (40-227): 2.16e-42: 152: 19.10
+	Hs
		819567 DLG1_HUMAN (87-235): 1.55e-13: 73.5: 17.31		KCNC1_HUMAN (40-227): 8.02e-43: 152: 19.10
+	Mm
		1143350 DLG4_MOUSE (106-233): 1.85e-14: 76.2: 21.48		KCD12_MOUSE (17-170): 9.55e-41: 143: 24.52
+	Hs
		1050010 SCRIB_HUMAN (4-185): 3.63e-13: 72.7: 18.37		SHKB1_HUMAN (40-150): 1.22e-35: 135: 40.54