HitPredict

Interactor 1: NHRF2 (Q15599)
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF-2) (NHE3 kinase A regulatory protein E3KARP) (SRY-interacting protein 1) (SIP-1) (Sodium-hydrogen exchanger regulatory factor 2) (Solute carrier family 9 isoform A3 regulatory factor 2) (Tyrosine kinase activator protein 1) (TKA-1)
Gene: NHERF2

Interactor 2: GIT1 (Q9Y2X7)
ARF GTPase-activating protein GIT1 (ARF GAP GIT1) (Cool-associated and tyrosine-phosphorylated protein 1) (CAT-1) (CAT1) (G protein-coupled receptor kinase-interactor 1) (GRK-interacting protein 1) (p95-APP1)
Gene: GIT1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005925 - focal adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 337 Hs			1 761
+	Hs
		153960 NHRF1_HUMAN (2-337): 3.61e-70: 224: 48.87		GIT1_HUMAN (1-761): 1.3e-176: 527: 100.00
+	Hs
		1050110 NHRF2_HUMAN (1-337): 6.02e-79: 246: 100.00		GIT2_HUMAN (1-758): 2.93e-147: 451: 64.39
+	Hs
		1050094 SCRIB_HUMAN (4-185): 3.63e-13: 72.7: 18.37		GIT1_HUMAN (1-761): 1.3e-176: 527: 100.00
+	Hs
		1020239 PTN13_HUMAN (89-239): 2.59e-11: 66.9: 21.05		GIT1_HUMAN (1-761): 1.3e-176: 527: 100.00
+	Mm
		1143335 DLG4_MOUSE (106-233): 1.85e-14: 76.2: 21.48		GIT1_MOUSE (1-761): 7.5e-170: 509: 96.62
+	Hs
		1049946 SCRIB_HUMAN (4-185): 3.63e-13: 72.7: 18.37		GIT2_HUMAN (1-758): 2.93e-147: 451: 64.39
+	Mm
		100127 F6UDT8_MOUSE (4-328): 3.45e-48: 167: 18.92		AGAP2_MOUSE (2-223): 9.71e-49: 188: 29.28
+	Hs
		1021587 DLG1_HUMAN (87-235): 1.55e-13: 73.5: 17.31		ASAP1_HUMAN (2-606): 1.67e-61: 226: 17.06
+	Hs
		1300695 MAGI1_HUMAN (2-204): 1.44e-16: 83.1: 21.95		AGAP1_HUMAN (2-223): 4.13e-57: 211: 32.89
+	Mm
		1112635 DLG2_MOUSE (79-232): 1.54e-14: 76.5: 18.63		AGAP2_MOUSE (2-223): 9.71e-49: 188: 29.28
+	Mm
		1112581 DLG4_MOUSE (106-233): 1.85e-14: 76.2: 21.48		AGAP2_MOUSE (2-223): 9.71e-49: 188: 29.28
+	Mm
		88312 D3YUZ8_MOUSE (129-232): 1.78e-14: 76.2: 25.23		AGAP2_MOUSE (2-223): 9.71e-49: 188: 29.28
+	Mm
		1112610 DLG1_MOUSE (87-235): 9.49e-14: 74.2: 17.31		AGAP2_MOUSE (2-223): 9.71e-49: 188: 29.28
+	Hs
		280069 MPDZ_HUMAN (7-184): 3.68e-14: 75.7: 21.16		TNKS2_HUMAN (135-556): 6.36e-46: 179: 10.94
+	Mm
		1112570 Q52KF7_MOUSE (89-220): 1.11e-09: 61.5: 17.99		AGAP2_MOUSE (2-223): 9.71e-49: 188: 29.28
+	Hs
		167027 WHRN_HUMAN (3-250): 2.49e-40: 152: 22.22		ANR28_HUMAN (52-250): 1.89e-18: 92.5: 11.06
+	Hs
		1200078 NHRF4_HUMAN (4-91): 1.55e-11: 67.2: 33.71		ASAP3_HUMAN (2-438): 3.4e-45: 176: 17.89
+	Hs
		280009 MPDZ_HUMAN (7-184): 3.68e-14: 75.7: 21.16		TNKS1_HUMAN (60-480): 1.04e-37: 154: 12.78
+	Mm
		103602 DLG4_MOUSE (106-233): 1.85e-14: 76.2: 21.48		ANK3_MOUSE (237-740): 1.36e-20: 99.9: 9.25
+	Hs
		166999 SNX27_HUMAN (149-228): 1.89e-09: 60.8: 38.71		ANR28_HUMAN (52-250): 1.89e-18: 92.5: 11.06