HitPredict - High confidence protein-protein interactions

Method score	Annotation score	Interaction score
0.80	0.90	0.854

Property	Details
Experiments	30561431, 7758105, 11684708, 14743216
Identification Methods	affinity chromatography technology, two hybrid, coimmunoprecipitation, virotrap, tandem affinity purification, pull down
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Death~Death
Common GO terms	GO:0002947 - tumor necrosis factor receptor superfamily complex GO:0005068 - transmembrane receptor protein tyrosine kinase adaptor activity GO:0005164 - tumor necrosis factor receptor binding GO:0005634 - nucleus GO:0005737 - cytoplasm and 23 others more... GO:0005829 - cytosol GO:0005856 - cytoskeleton GO:0005886 - plasma membrane GO:0006915 - apoptotic process GO:0007165 - signal transduction GO:0007249 - canonical NF-kappaB signal transduction GO:0008625 - extrinsic apoptotic signaling pathway via death domain receptors GO:0009898 - cytoplasmic side of plasma membrane GO:0019900 - kinase binding GO:0030335 - positive regulation of cell migration GO:0031264 - death-inducing signaling complex GO:0033209 - tumor necrosis factor-mediated signaling pathway GO:0043065 - positive regulation of apoptotic process GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0043235 - receptor complex GO:0044877 - protein-containing complex binding GO:0050729 - positive regulation of inflammatory response GO:0051092 - positive regulation of NF-kappaB transcription factor activity GO:0051798 - positive regulation of hair follicle development GO:0060090 - molecular adaptor activity GO:0070513 - death domain binding GO:0071356 - cellular response to tumor necrosis factor GO:0097191 - extrinsic apoptotic signaling pathway
Homologous interactions	0